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Last update: Hodačová Jana doc. Dr. Ing. (10.04.2014)
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Last update: Hodačová Jana doc. Dr. Ing. (10.04.2014)
Students will be able to:
do stereochemical analysis of organic compounds and their reactions
propose a suitable synthetic method for the preparation of the desired stereoizomer of a product
prepare chiral non-racemic compound and determine its enantiomerical purity |
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Last update: Hodačová Jana doc. Dr. Ing. (10.04.2014)
R: Eliel, E. L.; Wilen, S. H.: Stereochemistry of Organic Compounds, John Wiley & Sons, New York, 1994. ISBN 978-0-471-01670-0.
R: Atkinson, R. S.: Stereoselective Synthesis, Wiley, Chichester, 1995. ISBN 978-0-471-95419-4.
A: Helmchen, G.; Hoffmann, R. W.; Mulzer, J.; Schaumann, E.: Stereoselective Synthesis v serii Methods of Organic Chemistry, Houben-Weyl, Vol. 21a-21f, 4. vydání, Thieme, Stuttgart, 1995. ISBN 9783131001146. |
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Last update: Hodačová Jana doc. Dr. Ing. (10.04.2014)
A teacher will provide the study materials related to the lectures. |
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Last update: Hodačová Jana doc. Dr. Ing. (10.04.2014)
1. Chirality. Stereochemical nomenclature.
2. Stereochemical analysis of organic compounds and reactions.
3. Racemization, enantiomerzsation, epimerization, diastereomerization.
4. Analytical methods in organic stereochemistry.
5. Methods of obtaining enantiomers.
6. Principles of stereoselective syntheses.
7. Relative stereochemistry control via cyclic tranzition state or cyclic intermediate.
8. Enantioselective reactions with use of chiral auxiliary.
9. Enantioselective reactions with use of chiral stoichiometric reagent.
10. Enantioselective metallocatalysis - a formation of the C-O and C-N bond.
11. Enantioselective metallocatalysis - a formation of the C-H and C-C bond.
12. Enantioselective organocatalysis.
13. Enantioselective catalysis with enzymes.
14. Strategy of stereoselective syntheses. |
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Last update: Hodačová Jana doc. Dr. Ing. (23.04.2014)
To pass two semestral tests and an exam. |
Coursework assessment | |
Form | Significance |
Examination test | 50 |
Continuous assessment of study performance and course -credit tests | 20 |
Oral examination | 30 |