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Last update: Rybáčková Markéta Ing. Ph.D. (11.09.2023)
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Last update: Rybáčková Markéta Ing. Ph.D. (11.09.2023)
Students will be able to: work under inert atmosphere using an inert line and septum techniques work at low temperatures work in a glovebox work with a microwave reactor work with an instrument for flash chromatography work with low-boiling liquids work with organometallic and hydride reagents measure UV spectra and analyse a reaction mixture by HPLC |
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Last update: Rybáčková Markéta Ing. Ph.D. (11.09.2023)
Printed experiment procedures. |
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Last update: Rybáčková Markéta Ing. Ph.D. (11.09.2023)
Printed experimental procedures. |
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Last update: Rybáčková Markéta Ing. Ph.D. (11.09.2023)
1. Determination of unknown concentration of butyllithium solution – working under inert atmosphere using inert lines and septum techniques. 2. Birch reduction of o-xylene – working with low-boiling liquids, working at low temperature, determination of reaction conversion by NMR spectroscopy. 3. Reduction of a carboxylic acid ester – working with hydride reagents under inert atmosphere, crystallization, determination of product purity by NMR spectroscopy. 4. Acylation of cyclohexanone - utilization of enamines in organic synthesis, working with Dean-Stark apparatus, vacuum distillation. 5. Horner-Wadsworth-Emmons reaction – working with sodium hydride under inert atmosphere, crystallization, determination of product purity by NMR spectroscopy. 6. Negishi cross-coupling – working with organozinc reagents under inert atmosphere, column chromatography. 7. Photochemical oxidation of sulfides to sulfoxides – measurement of UV spectra, calculation of extinction coefficient, weighing on an analytical balance, analysis of the reaction mixture by HPLC. 8. Ring-closing metathesis – working in a glovebox, kinetic study using NMR spectroscopy. 9. Microwave heating in organic synthesis - working with a microwave reactor, identification of an unknown sample. 10. Introduction into separation techniques in organic synthesis - separation of a product mixture via flash chromatography. |
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Last update: Kundrát Ondřej Ing. Ph.D. (22.02.2018)
No. |
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Last update: Rybáčková Markéta Ing. Ph.D. (06.08.2019)
Defense of an individual project. |
Teaching methods | ||||
Activity | Credits | Hours | ||
Konzultace s vyučujícími | 0.5 | 14 | ||
Účast v laboratořích (na exkurzi nebo praxi) | 5 | 140 | ||
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 1.5 | 42 | ||
7 / 7 | 196 / 196 |