|
|
|
||
Last update: Svozil Daniel prof. Mgr. Ph.D. (26.01.2018)
|
|
||
Last update: Svozil Daniel prof. Mgr. Ph.D. (26.01.2018)
Students will know: How to prepare data for phylogenetic and comparative analysis Create phylogenetic trees from DNA or protein sequences Test quality of phylogenetic tree Understand phylogenetic algorithms such as UPGMA, WPGMA, Maximum parsimony, and Maximum likelihood Identify mutations in the cells of germinal and somatic lineage Identify small and large structure variants Annotate mutations and variants |
|
||
Last update: Svozil Daniel prof. Mgr. Ph.D. (26.01.2018)
R: Miloš Macholán: Základy fylogenetické analýzy, 978-80-210-6363-1, Masarykova univerzita Brno, 2014 R: Relichová Jiřina: Genetika populací, ISBN 978-80-210-4795-2, Masarykova univerzita Brno, 2009 A: Flegr: Evoluční biologie. Academia, 2009 A: Mark Jobling, Edward Hollox, Toomas Kivisild, Chris Tyler-Smith: Human Evolutionary Genetics, Garland Science, 2014 A: Baum, D. A., & S. D. Smith. 2013. Tree-Thinking: An Introduction to Phylogenetic Biology. A: Philip W. Hedrick: Genetics of populations, ISBN 978-0763757373, Jones and Bartlett Publishers Sudbury, USA, 2009 |
|
||
Last update: Svozil Daniel prof. Mgr. Ph.D. (26.01.2018)
on-line courses https://github.com/schatzlab/appliedgenomics https://github.com/quinlan-lab/applied-computational-genomics |
|
||
Last update: Svozil Daniel prof. Mgr. Ph.D. (10.01.2018)
Zápočet: úlohy ze cvičení Zkouška: písemný test, následná ústní zkouška 50/50 |
|
||
Last update: Svozil Daniel prof. Mgr. Ph.D. (26.01.2018)
1. Molecular phylogenetics analysis 2. Molecular evolution, evolution of genomes 3. Molecular clocks, UPGMA, WPGMA, neighbour joining 4. Phylogenetic tree, evolution models 5. Methods for phylogenetic tree reconstruction 6. Tree quality assessment 7. Human genome, population and genetic variability 8. Levels of genetic variability, Hardy-Weinberg equilibrium 9. Genetic drift, migration, isolation 10. Computational methods for detection of selection 11. Short genetic variation and their detection 12. Genetic diseases, mutations in germinal and somatic cells 13. Large structural variants 14. Annotation and interpretation of genetic variants |
|
||
Last update: Svozil Daniel prof. Mgr. Ph.D. (26.01.2018)
Molecular biology/genetics, biochemistry, Linux and bash, foundations of bioinformatics |
|
||
Last update: Svozil Daniel prof. Mgr. Ph.D. (26.01.2018)
A credit will be given based on exercises assigned during the seminars. The final exam consists of a written test followed by an oral exam. |
Teaching methods | ||||
Activity | Credits | Hours | ||
Účast na přednáškách | 1 | 28 | ||
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 1 | 28 | ||
Příprava na zkoušku a její absolvování | 1 | 28 | ||
3 / 3 | 84 / 84 |