Biopharmaceuticals - N320067
Title: Bioléčiva
Guaranteed by: Department of Biochemistry and Microbiology (320)
Faculty: Faculty of Food and Biochemical Technology
Actual: from 2021
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
For type:  
Guarantor: Fusek Martin prof. Ing. CSc.
Benešová Eva Ing. Ph.D.
Examination dates   Schedule   
Annotation -
Last update: TAJ320 (11.12.2013)
The subject "Biopharmaceuticals" is dedicated to a general description of rapidly developing field of pharmaceutical industry to the students. Main drugs produced by conventional biotechnological processes (antibiotics, alkaloids, etc.) will be mentioned in an abbreviated form and then recombinant technologies, which are used for the production of biodrugs, will be explained. In the general part of the course, attention will be paid to the differences in the production of small molecules and proteins, after that different types of biodrugs, their indications and functions in the human body, and pathology will be discussed. Students also have to prepare their own presentations on given topics.
Aim of the course -
Last update: TAJ320 (11.12.2013)

Students will get knowledge of

• basic processes for recombinant pharmaceuticals production

• basic analytical procedures

• main types of indications and pathologies in which biodrugs are applied

• main representatives = particular biodrugs

Literature -
Last update: Fialová Jana (13.08.2013)

R:Fusek M., Káš J., Ruml T., Bioléčiva � VŠCHT Praha, 2008, 9788070806784

A:Fusek M., Vitek L, Blahos J., Hajdúch M., Ruml T., Biologická léčiva - teoretické základy a klinická praxe, GRADA, 2012, 9788024737270

A: Walsh G., Biopharmaceuticals - biochemistry and biotechnology, Wiley, 2003, 0470843268

Learning resources -
Last update: Benešová Eva Ing. Ph.D. (12.08.2013)

Syllabus -
Last update: Benešová Eva Ing. Ph.D. (12.08.2013)

1. Biopharmaceuticals, history and the content of the subject

2. Biomacromolecules - structure, posttranslational modifications

3. Biomacromolecules - function

4. Analysis of biomacromolecules - methodology

5. Organisms used for biodrugs production and cell biology

6. Methods of fermentation - animal cell lines, genetic modifications

7. Isolation procedures - methodology

8. Overview of main biodrugs - monoclonal antibodies

9. Overview of main biodrugs - proteins and enzymes replacement therapy

10. Proteins and enzymes replacement therapy

11. Overview of main biodrugs -vaccines

12. Overview of main biodrugs - expression regulation and future prospects

13. Biodrugs safety and quality control

14. Commercial aspects - overview of main manufacturers and sales

Registration requirements -
Last update: Benešová Eva Ing. Ph.D. (12.08.2013)

Biochemistry (Biochemistry I)

Molecular Genetics

Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na zkoušku a její absolvování 2 56
3 / 3 84 / 84