SubjectsSubjects(version: 853)
Course, academic year 2019/2020
  
Introduction to Spectral Methods of Drug Analysis - N402059
Title: Úvod do spektrálních metod pro analýzu léčiv
Guaranteed by: Department of Analytical Chemistry (402)
Actual: from 2013
Semester: summer
Points: summer s.:3
E-Credits: summer s.:3
Examination process: summer s.:
Hours per week, examination: summer s.:2/0 Ex [hours/week]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Guarantor: Matějka Pavel prof. Dr. RNDr.
Examination dates   Schedule   
Annotation -
Last update: Matějka Pavel prof. Dr. RNDr. (31.08.2013)
The course introduces the basic overview of spectral methods used for pharmaceutical analysis. It is dedicated to methods of both elemental and molecular analysis. Furthermore, detection, identification and quantification of both active ingredients and excipients by methods of molecular spectroscopy is discussed. The attention is focused on simple data evaluation either from the qualitative point of view using spectral libraries, or to obtain quantitative results using simple regression models.
Aim of the course -
Last update: Matějka Pavel prof. Dr. RNDr. (31.08.2013)

Students will be able to:

Describe basic spectral methods suitable for elemental, molecular and phase analysis of pharmaceuticals, to explain their principles, typical instrumentation and data outputs.

Assess the suitability of individual techniques considering qualitative and quantitative analysis, the state of samples and the pharmaceutical formulation.

Use of both spectral libraries for identification of pharmaceutical components and simple chemometric models for quantitative description of multicomponent mixtures.

Literature -
Last update: Matějka Pavel prof. Dr. RNDr. (04.09.2013)

R:Moderní přístupy k farmaceutické analýze, Jiří Dohnal, Hana Brusová, Farmaceutická fakulta Veterinární a farmaceutické univerzity Brno, 2010, ISBN 9788073050856

A:Handbook of Spectroscopy, Editor(s): Prof. Dr. Guenter Gauglitz, Prof. Dr. Tuan Vo-Dinh, Wiley-VCH 2003, Print ISBN: 9783527297825 Online ISBN: 9783527602308

A:Encyclopedia of Spectroscopy and Spectrometry, 2nd Edition, By John Lindon, George E. Tranter, David Koppenaal, Elsevier ACADEMIC PRESS 2010, ISBN: 978-0-12-374417-3

Learning resources -
Last update: Matějka Pavel prof. Dr. RNDr. (31.08.2013)

electronic materials - lectures - available in the domain vscht.cz

Syllabus -
Last update: Matějka Pavel prof. Dr. RNDr. (31.08.2013)

1. Classification of spectroscopic methods based on their principles and analytical applications

2. Spectral methods for elemental pharmaceutical analysis - X-ray fluorescence analysis

3. Quantitative X-ray fluorescence analysis

4. Spectral methods for elemental pharmaceutical analysis - optical atomic spectrometry

5. Spectral methods for elemental pharmaceutical analysis - inorganic mass spectrometry

6. Methods of molecular spectroscopy - spectrophotometry, luminescence techniques

7. Identification of active ingredients and excipients - the use of spectral libraries and databases

8. Detection and identification of active ingredients and excipients - infrared spectrometry

9. Detection and identification of active ingredients and excipients - Ramanova spectrometry

10.Spectral methods for identification and quantification - NIR spectrometry

11.Methods of molecular spectrometry for quantitative pharmaceutical analysis

12.NMR spectrometry for solution analysis

13.Quantitative NMR spectrometry

14.Mass spectrometry for identification of pharmaceutical ingredients

Registration requirements -
Last update: Matějka Pavel prof. Dr. RNDr. (31.08.2013)

none

Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0,5 14
Účast na přednáškách 1 28
Příprava na zkoušku a její absolvování 1,5 42
3 / 3 84 / 84
Coursework assessment
Form Significance
Regular attendance 10
Examination test 90

 
VŠCHT Praha