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Last update: Hodačová Jana doc. Dr. Ing. (21.06.2018)
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Last update: Hodačová Jana doc. Dr. Ing. (21.06.2018)
Students will be able to:
do stereochemical analysis of organic compounds and their reactions
propose a suitable synthetic method for preparation of the desired stereoizomer of a product
select a suitable analytical method for studies of stereoizomers and stereoselective reactions |
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Last update: Hodačová Jana doc. Dr. Ing. (09.10.2018)
R: Eliel, E. L.; Wilen, S. H.: Stereochemistry of Organic Compounds, John Wiley & Sons, New York, 1994. ISBN 978-0-471-01670-0.
R: Gawley, R. E.; Aubé, J.: Principles of Asymmetric Synthesis, 2nd edition, Elsevier, Oxford, 2012. ISBN 978-0-08-044860-2 (e-book 978-0-08-0914138).
A: Helmchen, G.; Hoffmann, R. W.; Mulzer, J.; Schaumann, E.: Stereoselective Synthesis v serii Methods of Organic Chemistry, Houben-Weyl, Vol. 21a-21f, 4. vydání, Thieme, Stuttgart, 1995. ISBN 9783131001146. |
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Last update: Hodačová Jana doc. Dr. Ing. (21.06.2018)
A teacher will provide the study materials related to the lectures.
E-books available through the NTK web pages:
Mislow, K.: Introduction to Stereochemistry. Dover Publications, 2002. https://app.knovel.com/web/toc.v/cid:kpIS000015/viewerType:toc//root_slug:viewerType%3Atoc/url_slug:root_slug%3Aintroduction-stereochemistry?kpromoter=federation
Wolf, C.: Dynamic Stereochemistry of Chiral Compounds - Principles and Applications. Royal Society of Chemistry, 2007. https://app.knovel.com/web/toc.v/cid:kpDSCCPA01/viewerType:toc//root_slug:viewerType%3Atoc/url_slug:root_slug%3Adynamic-stereochemistry?kpromoter=federation
Jozwiak, K.: Drug Stereochemistry. 3rd edition. CRC Press, Boca Raton, 2012. https://www.taylorfrancis.com/books/e/978142009239
Torres, R. R.: Stereoselective Organocatalysis. JohnWiley & Sons, Inc., Hoboken, New Jersey, 2013. https://onlinelibrary.wiley.com/doi/book/10.1002/9781118604755
Schreier, P.; Huffer, M.; Bernreuther, A.: Analysis of Chiral Organic Molecules: Methodology and Applications. De Gruyter, Berlin, 1995. http://web.a.ebscohost.com.ezproxy.techlib.cz/ehost/detail/detail?vid=0&sid=9a38914a-8de0-44ec-a42d-0678d7e8cfe5%40sessionmgr4010&bdata=Jmxhbmc9Y3Mmc2l0ZT1laG9zdC1saXZl#AN=559497&db=nlebk |
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Last update: Hodačová Jana doc. Dr. Ing. (21.06.2018)
Lectures and seminars |
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Last update: Hodačová Jana doc. Dr. Ing. (21.06.2018)
1. Introduction to stereochemistry of organic compounds.
2. Stereochemical nomenclature.
3. Racemization, enantiomerzsation, diastereomerization.
4. Analytical methods in organic stereochemistry.
5. Enantiomerically pure natural compounds.
6. Racemates resolutions.
7. Overview and principles of stereoselective reactions.
8. Diastereoselective reactions.
9. Enantioselective reactions using a stoichiometric amount of a chiral reagent.
10. Enantioselective catalysis with the metal complexes.
11. Enantioselective organocatalysis.
12. Enantioselective catalysis with enzymes.
13. Comparison of the methods of stereoselective syntheses. |
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Last update: Hodačová Jana doc. Dr. Ing. (21.06.2018)
Knowledge of organic chemistry and organic synthesis at the Master level. |
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Last update: Hodačová Jana doc. Dr. Ing. (21.06.2018)
To pass two semestral tests and a final exam. |