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Synthetic strategies based on organocatalyzed processes, such as stereoselective aldol and Mannich reaction, Michael and Diels-Alder addition, Friedel-Crafts-like functionalization, allylation, transfer hydrogenation, and hydrosilylation, etc.
Last update: Fialová Jana (05.05.2022)
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Students will be able to: perceive organocatalytic reactions in terms known to you from the previous courses on organic chemistry and biochemistry recognise and understand the basic organocatalytic reactions understand the mechanisms of organocatalyzed reactions and to broaden the mechanistic understanding in general organic chemistry. identify conditions required for catalytic cycles to be efficient. use organocatalysis for designing key steps in the synthesis of organic molecules.
Last update: Fialová Jana (05.05.2022)
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R: Wiley-VCH, Ullmann's Fine Chemicals, Wiley-VCH; 1st edition (January 7, 2014), ISBN 978-3527334773
A: Stephen O. Duke, Per Kudsk, Keith Solomon, Pesticide Dose: Effects on the Environment and Target and Non-Target Organisms, ACS Symposium series, 2017, ISBN13: 9780841232112, DOI: 10.1021/bk-2017-1249 A: F. Muller, Agrochemicals: Composition, Production, Toxicology, Applications, Wiley-VCH 2000 ISBN-13 : 978-3527298525 A: D. Cairns, Essentials of Pharmaceutical Chemistry 4th Edition, Pharmaceutical Press; 4th edition (January 1, 2012), ISBN 978-0853699798 A: D. Myers, Surfactant Science and Technology, Wiley; 4th edition (June 23, 2020). ISBN 978-1119465850 A: Hans Zweifel, Plastics Additives Handbook, Hanser Publications; 6th edition (June 4, 2009), ISBN 978-1569904305 Last update: Vyskočilová Eliška (09.05.2022)
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https://en.wikipedia.org/wiki/Fine_chemical Last update: Vyskočilová Eliška (09.05.2022)
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1. Introduction. 2. Catalysis via Enamines; Aldol reactions, Mannich reactions,α-Heteroatom Functionalization, Michael Additions. 3. Catalysis via Iminium Ions; Cycloadditions, Michael additions, Epoxidations. 4. Brønsted Acids as Catalysts; Michael addition, Hydrocyanation, Mannich reaction, Aza-Henry reaction, Aza-Friedel-Crafts reaction, Pictet-Spengler Reaction, Transfer Hydrogenation, Morita-Baylis-Hillman Reaction, Diels-Alder Reaction. 5. Lewis Bases as Catalysts; Allylation of Aldehydes, Aldol-Type Reactions, Hydrocyanation, Hydrosilylation, Reduction of Imines, Reduction of Ketones. 6. Epoxidation.
Last update: Fialová Jana (05.05.2022)
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Activity on the lectures and sucesfully passed oral exam. Last update: Vyskočilová Eliška (09.05.2022)
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