Subjects

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Bioinorganic Chemistry - D101007

Title:	Bioanorganická chemie
Guaranteed by:	Department of Inorganic Chemistry (101)
Faculty:	Faculty of Chemical Technology
Actual:	from 2013 to 2013
Semester:	winter
Points:	winter s.:0
E-Credits:	winter s.:0
Examination process:	winter s.:
Hours per week, examination:	winter s.:0/0, other [HT]
Capacity:	unknown / unknown (unknown)
Min. number of students:	unlimited
State of the course:	taught
Language:	Czech
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Note:	course is intended for doctoral students only

Guarantor:	Lukeš Ivan prof. RNDr. CSc. Hoskovcová Irena Ing. CSc.

Examination dates Schedule

Annotation -

The course focuses on the role transition metals in molecular structure and properties. It makes students familiar with common theories used for description of coordination compounds. It describes role of key properties of both metals and ligands which enable formation of coordination compounds and influence their properties (e.g. reactivity, biological activity, IR and UV-Vis spectra, magnetic behaviour).

Last update: TAJ101 (26.08.2013)

Aim of the course -

Students will be able to:

Understand and use basic terms common in coordination chemistry field

Distinguish between CFT, LFT and MO approach, to know their individual advantages and applicability

Explain typical properties of coordination compounds with help of an appropriate model

Read specialized monographs and articles concerning Coordination chemistry

Last update: VED101 (14.05.2014)

Course completion requirements -

Presentation of a selected topic. Oral exam.

Last update: Hoskovcová Irena (17.04.2014)

Literature -

Z: R. R. Crichton, Biological Inorganic Chemistry, 2nd ed., Elsevier 2011, ISBN: 978-0-444-53782-9

D: W. Kaim. B. Schwederski, A. Klein: Bioinorganic chemistry, 2nd ed. Wiley 2013

Last update: Hoskovcová Irena (17.04.2014)

Syllabus -

1. Formal oxidation states and coordination stereochemistry of biologically important metals

2. Stability constants, kinetics and reaction mechanisms of metal complexes

3. Metal ions uptake and their transmembrane flow

4. Metal transport and storage in vivo

5. Myoglobin and haemoglobin. Haemerythrin, haemocyanin.

6. Hydrolysis, carboxypeptidase A, phosphates, hydrolyases, aconitase.

7. Cofactores and coenzymes in redox metalloproteins

8. Iron and sulphur containing clusters, haem.

9. Cupper ions and their complexes

10. Molybdenum, cobalamines, nickel-containing coenzymes

11. Electron-transfer in mitochondria

12. Overview of the 1st and 2nd group metals role in biological systems

13. Enzyme activation, complexes with nucleic acids, biominerals, skeleton.

14. Oxygen toxicity, metal toxicity. Coordination compounds in therapy and diagnostics.

Last update: Hoskovcová Irena (17.04.2014)

Registration requirements -

General and Inorganic Chemistry II, Biochemistry

Last update: TAJ101 (26.08.2013)

Coursework assessment
Form	Significance
Regular attendance	20
Examination test	30
Continuous assessment of study performance and course -credit tests	20
Oral examination	30