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The characterization of biological processes catalyzed by enzymes or microbial cells is carried out by models including kinetic and mass balance equations. This course is therefore focused on creating mass and energy balances and their application in mathematical models describing the studied systems. These models of biological systems will be used to predict the behaviour of systems im limit cases and in scale-up (down) processes.
Last update: Halecký Martin (16.09.2023)
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Student will be able to: Independently carry out mass balances of different biotechnological processes. Extend the mass balances with kinetic equations describing the dynamic aspects of the system. Estimate the key process parameters and by using them describe the scale-up (down) of bioprocesses. Last update: Halecký Martin (16.09.2023)
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R - Meyer H.-P., & Schmidhalter D. (2014). Industrial Scale Suspension Culture of Living Cells. Wiley, ISBN: 978-3-527-68335-2 R - Katoh S., Horiuchi J., & Yoshida F. (2015). Biochemical Engineering: A Textbook for Engineers, Chemists and Biologists. Wiley, ISBN: 9783527338047 R - Kresta, S. M., Etchells, A. W., Dickey, D. S., & Atiemo-Obeng, V. A. (2016). Advances in industrial mixing: a companion to the Handbook of industrial mixing. Wiley, ISBN: 9781118944301 Last update: Halecký Martin (16.09.2023)
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The structure of bioprocesses, overview of equipment and unit operations. The methods and procedure of biological processes modeling. Mass and energy balancess. Kinetics of enzymatic reactions and microbial growth. Scale-up and scale-down of bioprocesses. Criteria of scale-up, principles of similarity (geometric, kinetic, dynamic) Dimensional analysis. Last update: Halecký Martin (16.09.2023)
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None Last update: Halecký Martin (16.09.2023)
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| Coursework assessment | |
| Form | Significance |
| Regular attendance | 20 |
| Defense of an individual project | 20 |
| Oral examination | 60 |