Subjects

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Chemical Biology - N143045

Title:	Chemická biologie
Guaranteed by:	Department of Informatics and Chemistry (143)
Faculty:	Faculty of Chemical Technology
Actual:	from 2013 to 2020
Semester:	summer
Points:	summer s.:3
E-Credits:	summer s.:3
Examination process:	summer s.:
Hours per week, examination:	summer s.:2/0, Ex [HT]
Capacity:	unknown / unknown (unknown)
Min. number of students:	unlimited
State of the course:	taught
Language:	Czech
Teaching methods:	full-time
Teaching methods:	full-time
Level:

Guarantor:	Bartůněk Petr RNDr. CSc.

Examination dates Schedule

Annotation -

Chemical biology is a modern scientific field at the borderline between chemistry and biology. It uses small organic compounds to affect various biological processes. A chemical biology course covers a territory where organic chemistry, molecular and cell biology, cheminformatics and bioinformatics meet. The course will introduce small molecules as tools for subsequent biology research or as a basis for novel drug development.

Last update: ROZ143 (09.07.2013)

Aim of the course -

Students will be able to:

Understand how small molecules bind to various molecular targets.

Understand how small molecules affect e.g. protein-protein interactions or signalling cell pathways.

Know basic methods for molecular target identification, experimental bioactivity high throughput testing, and basic principles of molecular tools or drugs development.

Last update: ROZ143 (09.07.2013)

Literature -

R: Schreiber Stuart L., Kapoor Tarun M., Wess Günther, Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Wiley-VCH 2007, ISBN: 3527311505

R: Waldmann Herbert, Janning Petra, Chemical Biology, Wiley-VCH 2009, ISBN: 3527323309

A: Alberts Bruce, Molecular Biology of the Cell, Taylor & Francis 2008, ISBN: 0815341113

Last update: ROZ143 (09.07.2013)

Syllabus -

1. Introduction to chemical biology: history and modern approaches

2. Small molecules, natural products, peptides, DNA/RNA

3. Principles and methods in chemical biology

4. High-throughput screening

5. Molecular tools development

6. Protein-protein interactions

7. Cell signalling pathways

8. Phenotype tests

9. Model organisms and chemical genetics

10. Molecular targets identification

11. Drug development and pharmacology

12. Combinatorial approaches in chemical biology

13. Small molecules and system biology

14. Informatics in chemical biology

Last update: ROZ143 (09.07.2013)

Learning resources -

Video course "Introduction to Chemical Biology", University of California Irvine, http://www.youtube.com/playlist?list=PLqOZ6FD_RQ7nT_YuhXKJVEDPjGvj5Lspa

Last update: ROZ143 (09.07.2013)

Registration requirements -

Organic chemistry, Biochemistry

Last update: ROZ143 (09.07.2013)

Teaching methods
	Activity	Credits	Hours
	Účast na přednáškách	1	28
	Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi	1	28
	Příprava na zkoušku a její absolvování	1	28
		3 / 3	84 / 84

Coursework assessment
Form	Significance
Examination test	100