Subjects

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Biomolecular Interactions - N143047

Title:	Interakce biomolekul
Guaranteed by:	Department of Informatics and Chemistry (143)
Faculty:	Faculty of Chemical Technology
Actual:	from 2013 to 2018
Semester:	summer
Points:	summer s.:3
E-Credits:	summer s.:3
Examination process:	summer s.:
Hours per week, examination:	summer s.:2/0, Ex [HT]
Capacity:	unknown / unknown (unknown)
Min. number of students:	unlimited
State of the course:	taught
Language:	Czech
Teaching methods:	full-time
Teaching methods:	full-time
Level:

Guarantor:	Vondrášek Jiří prof. RNDr. CSc.

Examination dates Schedule

Annotation -

During the course basic concept of interactions between biomolecules (proteins, nucleic acids, and small ligands) are explained. The main focus of the lectures will be on noncovalent interactions. Theoretical methods of their description, such as e.g. phenomenological potentials and their applications will be explained. Students will further gain knowledge of the design of protein-protein, protein-NA or protein-ligand interactions.

Last update: TAJ143 (03.12.2013)

Aim of the course -

Students will be able to:

Understand physico-chemical principles of noncovalent interactions.

Know categories of biomolecular interactions.

Understand basic statistical and computational tools for working with biomolecular interactions.

Master basic concepts of phenomenological potentials.

Predict interactions between biomolecules.

Last update: ROZ143 (06.08.2013)

Literature -

R: Jin Xiong, Essential Bioinformatics, Cambridge University Press 2006, ISBN: 978-0-521-60082-8

R: Peter Schuck (ed.), Protein Interactions, Springer 2007, ISBN: 0-387-35965-6

Last update: ROZ143 (06.08.2013)

Syllabus -

1. Biomolecular interactions - basic concepts

2. Quaternary structure of proteins and its modelling.

3. Interactions between proteins and nucleic acids.

4. Potential energy surface and its construction.

5. Docking algorithms I - principles.

6. Docking algorithms I - oveview of common approaches.

7. Docking protocols.

8. CAPRI.

9. Protein Structure Initiative and computational proteomics.

10. Design of protein-protein interactions.

11. Targeted increase of biomolecular affinity.

12. Rational design of the specificity regulation.

13. Interactome

14. Interaction networks and their construction.

Last update: ROZ143 (06.08.2013)

Learning resources -

none

Last update: ROZ143 (06.08.2013)

Registration requirements -

Biochemistry

Last update: ROZ143 (07.08.2013)

Teaching methods
	Activity	Credits	Hours
	Účast na přednáškách	1	28
	Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi	1	28
	Příprava na zkoušku a její absolvování	1	28
		3 / 3	84 / 84

Coursework assessment
Form	Significance
Examination test	100