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A number of secondary metabolites are among important biotech products used in medicine, food and chemical industry and in many other areas of human activity. Although metabolic pathways for the synthesis of these compounds are based on metabolites of the general (primary) metabolism, they are specific to particular groups of organisms and have different regulatory mechanisms. The lectures explain the general relationships between primary and secondary metabolism and evolution of metabolic pathways of secondary metabolism. After a survey of the individual groups of secondary metabolites, closer attention is paid to microbial and plant compounds such as antibiotics, cancerostatics, alkaloids, terpenic oils etc.. In detail are discussed its biosynthetic pathways, physico-chemical properties, biological activity, the mechanisms of interaction with other organisms and resistance to their effects. Part of the seminar is an individual work devoted to a selected group of secondary metabolites.
Last update: TAJ319 (10.12.2013)
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Students will be able to: characterize important groups or individual compounds produced by secondary metabolism; describe the important metabolic pathways for the synthesis of secondary metabolites and their regulation; propose application of the most important secondary metabolites; recognize the risks associated with the mechanism and evolution of resistance to secondary metabolites such as used in medicine, food, etc. Last update: TAJ319 (10.12.2013)
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R:Rehm,H.-J.,Reed G.: Biotechnology: Products of Secondary Metabolism, Vol 7, 2nd Ed, Wiley, Weinheim, 2008, 9783527620890 A:Cole,R.J.: Handbook of Secondary Fungal Metabolites, Elsevier, New York,2003, 978012179606 A:Crozier,A:Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet,Wiley, Oxford, 2006, 978145125093 Last update: TAJ319 (30.08.2013)
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1. Introduction - definitions of "secondary metabolism", "secondary metabolite" 2. Origin, evolution and genetic determination of secondary metabolism 3. Distribution and function of secondary metabolism in living organisms 4. List of important metabolic pathways of secondary metabolism and their regulation 5. Overview of the biological activities of secondary metabolites 6. Secondary metabolism in microorganisms 7. Antimicrobial compounds 8. Secondary metabolites with cancerostatic activity 9. Microbial toxins 10. Microbial alkaloids and growth modulators 11. Secondary metabolites produced by plants I 12. Secondary metabolites produced by plants II 13. Resistance mechanisms against the toxic effects of secondary metabolites 14. Current trends in research and application of secondary metabolites Last update: Masák Jan (30.08.2013)
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http://eso.vscht.cz/ Last update: Masák Jan (30.08.2013)
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Biochemistry, Microbiology, Organic chemistry Last update: Masák Jan (30.08.2013)
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| Teaching methods | ||||
| Activity | Credits | Hours | ||
| Konzultace s vyučujícími | 0.5 | 14 | ||
| Účast na přednáškách | 1 | 28 | ||
| Práce na individuálním projektu | 1 | 28 | ||
| Příprava na zkoušku a její absolvování | 1 | 28 | ||
| Účast na seminářích | 0.5 | 14 | ||
| 4 / 4 | 112 / 112 | |||
| Coursework assessment | |
| Form | Significance |
| Regular attendance | 30 |
| Defense of an individual project | 30 |
| Oral examination | 40 |