Subjects

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Methods of Pharmaceuticals Analysis - N402055

Title:	Metody analýzy léčiv
Guaranteed by:	Department of Analytical Chemistry (402)
Faculty:	Faculty of Chemical Engineering
Actual:	from 2019 to 2020
Semester:	winter
Points:	winter s.:5
E-Credits:	winter s.:5
Examination process:	winter s.:
Hours per week, examination:	winter s.:3/0, Ex [HT]
Capacity:	unknown / unknown (unknown)
Min. number of students:	unlimited
State of the course:	taught
Language:	Czech
Teaching methods:	full-time
Level:
Is provided by:	M402046

Guarantor:	Sýkora David prof. Dr. RNDr.
Is interchangeable with:	M402046

Examination dates Schedule

Annotation -

Principles and applications of frequently used analytical methods in pharmaceutical laboratories are discussed with focus on separation techniques and other relevant methods.

Last update: Sýkora David (26.09.2016)

Literature -

R: High Performance Capillary Electrophoresis - firemní příručka, D.N. Heiger, Hewlett-Packard, 1992.

R: Basic Gas Chromatography - kniha, H.M. McNair and J.M. Miller, Wiley, 2009, ISBN: 978-0-470-43954-8.

R: Practical High-Performance Liquid Chromatography - kniha, V.R. Meyer, Wiley, 2010, ISBN:978-0-470-68218-0.

R: Introduction to Mass Spectrometry - kniha, J.T. Watson and O.D. Sparkman, Wiley, 2007, ISBN: 978-0-470-51634-8.

Last update: VED402 (01.10.2013)

Syllabus -

1. Introduction to the separation methods, their basic characterization.

2. Capillary electrophoresis and electrochromatography.

3. Gas Chromatography (GC). Principles, injection techniques, columns, detectors.

4. Liquid chromatography (LC). Principles, separation modes, instrumentation, sorbents and columns, detectors.

5. Supercritical fluid chromatography. Principles and instrumentation.

6. Simulated Moving Bed technique. Description of the method, applications.

7. Solid phase extraction. Principles and applications.

8. Mass spectrometry (MS). Ionization techniques, analyzers, detectors, GC-MS a LC-MS.

9. Methods of drug analysis in solid phase.

10. Polymorphism of API and analytical methods used for their detection.

11. Dissolution and adsorption of drugs.

12. Spectroscopic techniques of drug analysis - 1.

13. Spectroscopic techniques of drug analysis - 2.

14. Registration of new pharmaceuticals.

Last update: Sýkora David (26.09.2016)

Learning resources -

http://onlinelibrary.wiley.com/book/10.1002/9780470688427

Last update: Sýkora David (16.08.2013)

Learning outcomes -

Students will obtain knowledge on many important analytical techniques applied in pharma laboratories. The most frequently used techniques will be covered in detail.

Last update: Sýkora David (26.09.2016)

Entry requirements -

The students need to know analytical chemistry on the level of Analytical chemistry I.

Last update: Sýkora David (12.02.2018)

Registration requirements -

The students need to know analytical chemistry on the level of Analytical chemistry I.

Last update: Sýkora David (12.02.2018)

Teaching methods
	Activity	Credits	Hours
	Konzultace s vyučujícími	0.5	14
	Účast na přednáškách	1.5	42
	Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi	0.5	14
	Příprava na zkoušku a její absolvování	2.5	70
		5 / 5	140 / 140

Coursework assessment
Form	Significance
Regular attendance	20
Examination test	80