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The course focuses on understanding and quantitative description of biological processes in the context of their implementation under defined conditions enabling to achieve reproducibility of results. The syllabus is based on the principles of kinetics, balancing as well as measurement and regulation of biological processes, including the design of the equipment.
Last update: Halecký Martin (16.09.2023)
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Students will be able to: Understand the biological, chemical and engineering processes in the biotechnology industry Describe and evaluate basic biocatalytic processes. Quantitatively evaluate experimental data of processes catalyzed by biological elements and to carry out heat and mass balances of biotechnological processes. Design mixing and aeration equipment of bioreactors. Last update: Halecký Martin (16.09.2023)
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Credit test (rated at least 50%). Exam test (rated at least 50%). Oral exam. Last update: Halecký Martin (16.09.2023)
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R - Moo-Young M., (2019) Comprehensive Biotechnology. Elsevier, ISBN: 9780444640475 R - Katoh S., Horiuchi J., & Yoshida F. (2015). Biochemical Engineering: A Textbook for Engineers, Chemists and Biologists. Wiley, ISBN: 9783527338047 A - Meyer H.-P., & Schmidhalter D. (2014). Industrial Scale Suspension Culture of Living Cells. Wiley, ISBN: 978-3-527-68335-2 Last update: Halecký Martin (01.07.2024)
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1. Engineering aspects of biotechnology 2. The structure of bioprocess, equipment overview and unit operations 3. Methods of optimization and modeling of biological processes 4. Engineering kinetics of chemical and enzymatic reactions 5. Cultivation of microorganisms - kinetics of microbial growth, batch cultures 6. Cultivation of microorganisms - fed-batch, semicontinuous and continuous cultures 7. Characteristics of phase flow - residence time distribution, flow models 8. Mass transfer - oxygen transfer, aeration, measurement and quantification of kLa 9. Specific aspects of plant/tissue cell and phototrophic cell cultivation 10. Specific aspects of plant and tissue cell cultivation 11. Mixing in bioreactors - theory, power consumption, homogenization, shear force 12. Heat transfer, energy balance of bioreactors, sterilization, cooling and heating 13. Scale-up of bioprocesses 14. Construction materials and corrosion Last update: Halecký Martin (16.09.2023)
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https://e-learning.vscht.cz/course/view.php?id=455 Last update: Halecký Martin (16.09.2023)
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Teaching methods | ||||
Activity | Credits | Hours | ||
Konzultace s vyučujícími | 0.2 | 6 | ||
Účast na přednáškách | 1 | 28 | ||
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 0.5 | 14 | ||
Příprava na zkoušku a její absolvování | 1.8 | 50 | ||
Účast na seminářích | 0.5 | 14 | ||
4 / 4 | 112 / 112 |