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The course introduces the basic, structurally derived groups of natural compounds, their properties, reactions and occurrence in organism. It explains also basic concepts relating to structure of molecules, their stereochemistry and/or chirality, including structure-biological activity relationships, e.g. for narcotics. The course deals also with enzymatic and biomimetic reactions.
Last update: Kubová Petra (19.12.2017)
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Students will be able to: Classify natural compounds into individual structural classes Describe structure, properties and reactions of individual classes of natural compounds and their biogenesis Assess structure-reactivity relationships Depict reaction mechanisms of basic reaction types Last update: Kubová Petra (19.12.2017)
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R: McMurry J.: Organic chemistry, 8th Ed., Brooks/Cole, Cengage Learning, 2012, 9780840054449 Last update: Kubová Petra (19.12.2017)
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1. Definition of natural compounds and products 2. Stereochemistry of natural compounds 3. Structure-biogenesis relationships, metabolic pathways determination 4. Natural compounds derived from acetate 5. Saturated and unsaturated fatty acids and prostaglandins 6. Polyketides and their cyclization 7. Deoxysaccharides, aflatoxins, antibiotics 8. Natural compounds derived from mevalonate 9. Natural products derived from shikimate 10. Natural products derived from amino acids 11. Reactions with coenzymes and their mechanisms 12. Reduction, oxidation 13. Narcotics and their effects, legislation, placebo effect 14. Biomimetic reactions Last update: Kubová Petra (19.12.2017)
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Lecture notes Last update: Kubová Petra (19.12.2017)
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Organic chemistry I Organic chemistry II or Bioorganic chemistry of natural compounds Last update: Kubová Petra (19.12.2017)
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