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The aim of the lectures is to bring basic information in the chemistry of pharmaceuticals which should help the alumni to start their professional career in pharmaceutical industry (R&D, manufacture, Regulatory&Compliance etc.) and in the drug distribution. The introductory lectures cover general pharmaceutical chemistry: basic terms and definitions, primciples of mutual drug and organism interactions, drug design methods, registration of drugs, and good manufacturing practice. The main part of the lectures is devoted to a brief survey of structures and syntheses of the most frequently used drugs.
Last update: Kubová Petra (23.05.2016)
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Students will be: able to know basic therapeutic groups of drugs able to know the pharmacophores of the most frequently used drugs as well as the principles of their modes of action able to know syntheses of the most frequently used drugs informed on Regulatory&Compliance documentation for drug products (CTD Modul 3 - Quality) and will be able to participate in their preparation Last update: Kubová Petra (23.05.2016)
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D: Vardanyan R., Hruby V. : Syntheses of Essential Drugs. Elsevier, 2006. D: Patrick G. L. : An Introduction to Medicinal Chemistry. 3rd ed. Oxford University Press, Oxford 2005. D: Kleemann A.; Engel J. Pharmaceutical Substances, Syntheses, Patents, Applications. 4th ed. Stuttgart : Thieme, 2001.
Last update: Kubová Petra (23.05.2016)
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Student se může přihlásit na zkoušku pouze v případě, že má složenou zkoušku z Organické chemie I (N110004) nebo Organické chemie B (N110029). Last update: Kubová Petra (23.05.2016)
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1.Introduction. Basic terms and definitions. 2.Mutual drug and organism interactions. Basic terms in pharmacology. 3.Drug design methods. Registration of drugs. Good manufacturing practice. 4.Analgesics, antipyretics, anti-inflammatory agents. 5.Central nervous system drugs: anaesthetics, sedatives, hypnotics. 6.Central nervous system drugs: psychiatric drugs. 7.Autonomous nervous system drugs: sympathomimetics and sympatholytics. 8.Autonomous nervous system drugs: parasympathomimetics and parasympatholytics. Local anaesthetics and muscle relaxants. 9.Antihistamines and antiallergics. Antitussives and expectorants. 10.Cardiovascular system drugs. 11.Digestive tract therapeutic agents. 12.Antiinfective agents. 13.Chemotherapy of cancer. 14.Vitamins a hormones. Last update: Kubová Petra (23.05.2016)
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http://eso.vscht.cz/ Last update: Kubová Petra (23.05.2016)
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Fundamentals of Organic chemistry (J. McMurry: Organic Chemistry, 6th Ed. or equivalent) are considered as a prerequisite for attending the course. A student can be enrolled for Introduction into Chemistry of Pharmaceuticals after successful passing the entry test in organic chemistry. Last update: Kubová Petra (23.05.2016)
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Organic chemistry I, Pharmacology I. Last update: Kubová Petra (23.05.2016)
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