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SUPRAMOLECULAR CHEMISTRY is one of the most important innovations in inorganic/organic chemistry. Classical chemistry is based on the concept of covalent bonds which hold together the millions of currently known compounds. On the other hand, there are many processes in the Nature (e.g. enzyme-substrate interaction, immune response, complex formation, DNA replication etc.) which are enabled by the existence of intermolecular recognition based on the non-covalent interactions. These interactions, albeit much weaker that the covalent bonds, are responsible for reversibility of living processes in organisms, which is a fundamental prerequisite for function of living matter. As the direct study of non-covalent interactions in living organisms is too complicated, many simpler systems have been developed to mimic the biological functions on synthetic models. SUPRAMOLECULAR CHEMISTRY is highly interdisciplinary science dealing with study of basic principles of non-covalent interactions and their use in the design of artificial molecules capable of some function on molecular level - selective complexation, construction of receptors, self-assembly, molecular recognition etc.
Last update: Cibulka Radek (28.11.2013)
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Students will be able to: design the structure of artificial receptor for the complexation of cation or anion select suitable analytical method for the study of the structure of the complex suggest suitable analytical/spectroscopic methods for the measuring of the complexation constants and thermodynamic parameters for selected host-guest processes apply the principals of "self-assembly" for the synthesis of topological isomers use the principals of supramolecular chemistry in the advanced organic synthesis Last update: Cibulka Radek (22.08.2013)
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R: Jonathan W. Steed, Jerry L. Atwood: Supramolecular Chemistry, 2nd Edition, Wiley 2009. 9780470512340 A: Beer P. D., Gale P. A., Smith D. K.: Supramolecular Chemistry, Oxford Chemistry Primers, Oxford University Press 1999. 0198504470 A: Diderich F., Stang P. J., Tykwinski R. R. (Eds.): Modern Supramolecular Chemistry, Wiley 2008, ISBN: 978-3-527-31826-1. A: Lhoták P., Stibor I.: Molekulární Design; vysokoškolská skripta, vydavatelství VŠCHT Praha, 1997. 8070802952 A: kolektiv autorů: Supramolekulární chemie I, Cyklus Organická Chemie, svazek 29, 2004, ÚOCHB Praha. 8086241211 A: kolektiv autorů: Supramolekulární chemie II, Cyklus Organická Chemie, Svazek. 30, UOCHB AV ČR Praha, 2005. 8086241270 Last update: Lhoták Pavel (21.08.2013)
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1. What is supramolecular chemistry? Introduction and basic definitions. Chemistry of crownethers - complexation of cationts 2. Noncovalent intermolecular interactions 3. Anion complexation 4. Binding of neutral molecules, chiral recognition 5. Modular approach - the coordination chemistry of bipyridines 6. Calix[n]arenes and related macrocycles 7. Cyclodextrins, cucurbiturils, cyclotriveratrylenes 8. Chemistry of fullerenes, carbon nanotubes and other carbon allotropes 9. Dendrimers 10. The evaluation of the complexation ability - complexation constants 11. Self-assembly 12. Topological isomers (rotaxanes, catenanes, knotanes), nanomachines 13. Liquid crystals 14. Surfactants and interfacial ordering Last update: Lhoták Pavel (21.08.2013)
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Electronic materials available at the lecturer Last update: Cibulka Radek (28.08.2013)
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Organic chemistry II Last update: Cibulka Radek (26.08.2013)
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| Teaching methods | ||||
| Activity | Credits | Hours | ||
| Účast na přednáškách | 1 | 28 | ||
| Práce na individuálním projektu | 0.5 | 14 | ||
| Příprava na zkoušku a její absolvování | 2 | 56 | ||
| Účast na seminářích | 0.5 | 14 | ||
| 4 / 4 | 112 / 112 | |||
| Coursework assessment | |
| Form | Significance |
| Examination test | 50 |
| Oral examination | 50 |