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The subject "Biopharmaceuticals" is dedicated to a general description of rapidly developing field of pharmaceutical industry to the students. Main drugs produced by conventional biotechnological processes (antibiotics, alkaloids, etc.) will be mentioned in an abbreviated form and then recombinant technologies, which are used for the production of biodrugs, will be explained. In the general part of the course, attention will be paid to the differences in the production of small molecules and proteins, after that different types of biodrugs, their indications and functions in the human body, and pathology will be discussed. Students also have to prepare their own presentations on given topics.
Last update: TAJ320 (11.12.2013)
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Students will get knowledge of • basic processes for recombinant pharmaceuticals production • basic analytical procedures • main types of indications and pathologies in which biodrugs are applied • main representatives = particular biodrugs Last update: TAJ320 (11.12.2013)
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R:Fusek M., Káš J., Ruml T., Bioléčiva � VŠCHT Praha, 2008, 9788070806784 A:Fusek M., Vitek L, Blahos J., Hajdúch M., Ruml T., Biologická léčiva - teoretické základy a klinická praxe, GRADA, 2012, 9788024737270 A: Walsh G., Biopharmaceuticals - biochemistry and biotechnology, Wiley, 2003, 0470843268 Last update: Fialová Jana (13.08.2013)
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1. Biopharmaceuticals, history and the content of the subject 2. Biomacromolecules - structure, posttranslational modifications 3. Biomacromolecules - function 4. Analysis of biomacromolecules - methodology 5. Organisms used for biodrugs production and cell biology 6. Methods of fermentation - animal cell lines, genetic modifications 7. Isolation procedures - methodology 8. Overview of main biodrugs - monoclonal antibodies 9. Overview of main biodrugs - proteins and enzymes replacement therapy 10. Proteins and enzymes replacement therapy 11. Overview of main biodrugs -vaccines 12. Overview of main biodrugs - expression regulation and future prospects 13. Biodrugs safety and quality control 14. Commercial aspects - overview of main manufacturers and sales Last update: Benešová Eva (12.08.2013)
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www.sciencedirect.com Last update: Benešová Eva (12.08.2013)
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Biochemistry (Biochemistry I) Molecular Genetics Last update: Benešová Eva (12.08.2013)
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| Teaching methods | ||||
| Activity | Credits | Hours | ||
| Účast na přednáškách | 1 | 28 | ||
| Příprava na zkoušku a její absolvování | 2 | 56 | ||
| 3 / 3 | 84 / 84 | |||