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The course will cover the main aspects of Drug Design and Discovery, with a more particular emphasis on the medicinal chemistry methods and techniques used in this field. Some of the biological aspects, essential to the overall understanding of the topic, will also be covered.
Last update: Cibulka Radek (06.07.2022)
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Students will be able to: understand approaches to suggest suitable target understand principles of basic computational approaches for drug design understand approaches to develop leading structure know modern approaches for drug discovery.
Last update: Cibulka Radek (06.07.2022)
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It is compulsory to pass written examination test. Last update: Fialová Jana (05.05.2022)
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R:K. Stromgaard, P. Krogsgaard-Larsen, U. Madsen (Eds.): Textbook of Drug Design and Discovery, CRC Press, 5th Edition 2016; ISBN 9781032339948 R:R. B. Silverman, M. W. Holladay: The Organic Chemistry of Drug Design and Drug Action, Academic Press 2014; ISBN 978-0-12-382030-3 A: C. Rostron: Drug Design and Development, Oxford 2020; ISBN: 9780198749318 Last update: Cibulka Radek (06.07.2022)
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1. The Drug Design and Discovery process 2. Selecting the right target 3. How drugs work 4. Computer-aided drug design I: Structure-Based Drug Design 5. Computer-aided drug design I: Ligand-Based Drug Design 6. Natural compounds in Drug Discovery 7. Fragment-Based Drug Design 8. Hit discovery and lead optimisation I: Structure-Activity Relationships 9. Hit discovery and lead optimisation II: Hit-to-Lead 10. Hit discovery and lead optimisation III: Lead Optimisation 11. Prodrugs 12. Recent advances in Drug Design and Medicinal Chemistry 13. Drugs and their therapeutic landscape 14. Decision making in Drug Discovery Last update: Cibulka Radek (06.07.2022)
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http://en.wikipedia.org/wiki/Organocatalysis Last update: Fialová Jana (05.05.2022)
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