Subjects

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Chemistry and Physics of Solid Pharmaceuticals - B108005

Title:	Chemie a fyzika pevných léčiv
Guaranteed by:	Department of Solid State Chemistry (108)
Faculty:	Faculty of Chemical Technology
Actual:	from 2021
Semester:	both
Points:	3
E-Credits:	3
Examination process:
Hours per week, examination:	2/0, Ex [HT]
Capacity:	winter:unlimited / unknown (unknown) summer:unknown / unknown (unknown)
Min. number of students:	unlimited
State of the course:	taught
Language:	Czech
Teaching methods:	full-time
Level:
Note:	you can enroll for the course in winter and in summer semester

Guarantor:	Kratochvíl Bohumil prof. RNDr. DSc.
Interchangeability :	N108022

Examination dates

Annotation -

The lecture is focused on providing general knowledge of chemistry and physics of pharmaceutical solids. Great emphasis is put on the crystal structure and the resulting properties of drugs. Very important phenomenon of polymorphism and solid forms of active pharmaceutical substances (anhydrates, hydrates, salts, cocrystals) are discussed in more details. Chemical and physical degradation processes and products of solid API are also mentioned.

Last update: Kubová Petra (03.01.2018)

Literature -

R:Hilfiker R.(Ed.), Polymorphism in the Pharmaceutical Industry, Wiley-VCH Verlag, Weinheim, Germany, 2006, 9783527311460

Last update: Kratochvíl Bohumil (09.01.2018)

Syllabus -

1. Introduction to pharmaceutical solids

2. Crystal and amorphous phases

3. Molecular solids

4. Crystallization

5. Solubility and dissolution

6. Phenomenon of polymorphism

7. Examples of polymorphic systems

7. Solid forms of API’s (anhydrates, hydrates, salts, cocrystals)

8. Amorphous pharmaceutical phases

9. Size a shape of particles

10. Microstructure of dosage forms

11. Degradation processes in solids, stability tests

12. Photodegradation

13. Hygroscopicity

14. Patents

Last update: Kratochvíl Bohumil (09.01.2018)

Learning resources -

https://uchpel.vscht.cz/studium/studijni_materialy

Last update: Kratochvíl Bohumil (13.02.2018)

Learning outcomes -

Students will be able to:

understand the internal structure and arrangement of crystal and amorphous phases of solid pharmaceutical ingredients (API)

knowledgeable in polymorphism of anhydrates, hydrates, salts, cocrystals

predict possible degradation processes and products of solid API‘s

Last update: Kratochvíl Bohumil (09.01.2018)

Registration requirements -

Organic chemistry I, II

Fundamentals of Pharmacology

Last update: Kratochvíl Bohumil (13.02.2018)