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The course focuses on the toxicology and analytical chemistry of narcotic and psychotropic substances, with emphasis on their chemical, pharmacological, toxicodynamic, and toxicokinetic properties. It integrates knowledge from biophysical chemistry and neuropharmacochemistry as a foundation for understanding the mechanisms of action of various classes of psychoactive substances, including opioids, sedatives, cannabinoids, psychostimulants, hallucinogens, psychedelics, and selected natural drugs. The course also addresses the issue of doping and anabolic steroids.
The curriculum includes an overview of advanced analytical techniques used for the identification and quantification of drugs and their metabolites in both biological and non-biological matrices, in both clinical and forensic contexts. Emphasis is placed on field analysis capabilities, appropriate sample selection and collection, and drug profiling as part of forensic expertise aimed at identifying the origin and distribution routes of illicit substances.
The course also covers the legal framework related to narcotic and psychotropic substances and reflects current trends in the drug scene. The aim is to provide students with an interdisciplinary theoretical and practical foundation for work in toxicological, forensic, and clinical laboratories.
Last update: Kuchař Martin (13.04.2025)
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Condition for the oral exam: Successful completion of two interim tests with a minimum score of 50%. The course is concluded with an oral examination. Last update: Kuchař Martin (17.04.2025)
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R:Riedl O., Vondráček V. a spol.: Klinická toxikologie, Avicenum 1980. R:Marie Bičíková: Forenzní a klinická toxikologie, Praha, Galén, 2005, 2007. R:Heinz Lüllmann, Klaus Mohr, Martin Wehling: Farmakologie a toxikologie, Praha, Grada, 2004. Leslie A. King: Forensic Chemistry of Substance Misuse (A Guide to Drug Control), Cambridge, RSC Publishing, 2009. Last update: Fialová Jana (18.12.2017)
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• Lectures utilizing multimedia presentations and practical case studies focused on the effects of psychoactive substances in clinical and forensic contexts.
• Interactive frontal teaching: the instructor systematically presents key topics in toxicology and analytical chemistry while actively engaging students through questions, discussions, and reflection on real-life cases.
• In-class discussions are aimed at the critical evaluation of analytical findings, legislative aspects, and interdisciplinary connections in the field of drugs and addictive behavior.
• Work with case studies enables students to apply theoretical knowledge to model scenarios of clinical intoxications and forensic investigations. Last update: Kuchař Martin (17.04.2025)
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The final examination is conducted in the form of an oral assessment. Students are eligible to sit for the oral examination only upon fulfillment of the following conditions: Achievement of a minimum of 50% in the combined score of two continuous assessment tests; in justified cases, a comprehensive written test may be permitted as an alternative. The final grade is determined based on the outcome of the oral examination. Last update: Kuchař Martin (17.04.2025)
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1.Introduction, historical overview, legislation, drugs prevention and new trends. 2.Selected chapters from Biophysical Chemistry. 3.fyziology of neural system, receptors. 4.Opioids. 5.Sedatives. 6.Cannabinoids. 7.Analytical methods in clinical and forensic laboratory, field analysis and sampling. 8.Stimulants - cocaine. 9.Stimulants - ATS. 10.Stimulants - psychedelics. 11.Drugs profiling in forensic laboratory. 12.Halucinogens. 13.The others natural drugs. 14.Steroids and anabolic compounds. Last update: Kuchař Martin (13.04.2025)
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Lecture presentations in the form of materials for interim tests and the oral exam. Recommended literature. Kamil Kalina a kol.:Klinická adiktologie, Praha, Grada, 2015 Marie Balíková: Forenzní a klinická toxikologie, Praha, Galén, 2005, 2007. Heinz Lüllmann, Klaus Mohr, Martin Wehling: Farmakologie a toxikologie, Praha, Grada, 2004. Last update: Kuchař Martin (17.04.2025)
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Students will be able to:
Navigate national and EU legislation related to narcotic and psychotropic substances, including principles of classification and regulation.
Explain the basic neurochemical and toxicological mechanisms of action of major classes of psychoactive substances.
Describe current trends in the illicit drug market, including new psychoactive substances (NPS) and issues related to doping.
Apply fundamental forensic analysis principles to the identification of psychoactive substances using modern analytical techniques. Last update: Kuchař Martin (13.04.2025)
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There are no prerequisites required for this course. Last update: Kuchař Martin (17.04.2025)
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None Last update: Fialová Jana (18.12.2017)
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