SubjectsSubjects(version: 902)
Course, academic year 2021/2022
  
Fundamentals of Chemistry of Pharmaceuticals - AB110009
Title: Fundamentals of Chemistry of Pharmaceuticals
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2021
Semester: summer
Points: summer s.:5
E-Credits: summer s.:5
Examination process: summer s.:
Hours per week, examination: summer s.:3/0 [hours/week]
Capacity: 20 / unknown (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
Level:  
For type: Bachelor's
Additional information: http://předmět je vyučován pouze v letním semestru
Note: deregister from the exam date if a requisite was not fulfilled
course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Ménová Petra Ing. Ph.D.
Interchangeability : B110009, N110026, Z110026
Annotation -
Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)
The aim of the course is to provide the basics of the chemistry of pharmaceuticals which should help the students to start their professional career in pharmaceutical industry (R&D, manufacture) and in the drug distribution. The introductory lectures cover general pharmaceutical chemistry: basic terms and definitions, introduction to pharmacology, drug design and development. The main part of the course deals with the main drug therapeutic groups and highlights the structures and syntheses of the most frequently used drugs from each group.
Aim of the course -
Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)

Students will know:

basic pharmacological terms

methods of drug development and phases of drug testing

main therapeutic groups of drugs

pharmacophores of the most frequently used drugs and the principles of their modes of action

syntheses of the most frequently used drugs

Literature -
Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)

R: Vardanyan R., Hruby V. : Syntheses of Essential Drugs. Elsevier, 2006. 9780444521668

R: Patrick G. L.: An Introduction to Medicinal Chemistry. 6th ed. Oxford University Press, Oxford 2017. 9780198749691

R: Kleemann A.; Engel J.; Kutscher B.; Reichert D.: Pharmaceutical Substances, Syntheses, Patents, Applications. 5th ed. Stuttgart : Thieme, 2009. 9783135584058

All books are available at UCT Prague in the Central Library.

Requirements to the exam -
Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)

EXAMINATION

Before the oral examination, a written examination test is taken which has two parts, the overall time limit (parts A+B) is 100 minutes.

Part A: basic organic chemistry related to the API chemistry) and basid knowledge of Pharmacology (50 marks);

Part B: advanced organic chemistry focusing on API syntheses and on medicinal chemistry (50 marks);

The oral part of the examination only takes place if the student obtained at least 35 marks in the part A and at least 50 marks in total in the parts A and B of the written examination. If the student fails the examination, he/she is entitled to repeat it up to twice (i.e. each student is entitled one regular examination and two resits).

Syllabus -
Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)

1. Introduction. Basic terms and definitions

2. Introduction to pharmacology: pharmacokinetics and pharmacodynamics

3. Drug design and development; drug registration

4. Analgesics-antipyretics, non-steroidal anti-inflammatory agents

5. Opioid analgesics

6. Central nervous system drugs: anaesthetics, sedatives, hypnotics

7. Central nervous system drugs: psychiatric drugs

8. Autonomous nervous system drugs: sympathomimetics and sympatholytics

9. Autonomous nervous system drugs: parasympathomimetics and parasympatholytics

10. Local anaesthetics and myorelaxants

11. Antihistamines and antiallergics; treatment of cough

12. Cardiovascular system drugs

13. Digestive tract therapeutic agents

14. Antiseptics and antiinfective agents

Entry requirements -
Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)

Fundamentals of Organic chemistry (J. McMurry: Organic Chemistry, 6th Ed. or equivalent) are considered as a prerequisite for attending the course. A student can be enrolled for Fundamentals of Chemistry of Pharmaceuticals after successful passing the entry test of organic chemistry. More details and a specimen entry test can be found at https://uoch.vscht.cz/studying/bc-subjects/fcp

Registration requirements -
Last update: Kubová Petra Ing. (16.04.2018)

Organic Chemistry B (B110002) or Organic Chemistry II (B110004)

Course completion requirements -
Last update: Kundrát Ondřej Ing. Ph.D. (25.11.2021)

The exam is combined - the students have to successfully pass both a test and an oral part.

 
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