SubjectsSubjects(version: 887)
Course, academic year 2020/2021
Toxicology and Ecotoxicology I - AB240001
Title: Toxicology and Ecotoxicology I
Guaranteed by: Department of Environmental Chemistry (240)
Actual: from 2020 to 2020
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
For type: Bachelor's
Additional information: http://Předmět je vyučován pouze v zimním semestru. Zkoušky se konají u přednášejících.
Old code: ZTOE
Guarantor: Kočí Vladimír doc. Ing. Ph.D., MBA
Čapek Pavel doc. Ing. CSc.
McGachy Lenka Ing. Ph.D.
Interchangeability : S111009
This subject contains the following additional online materials
Annotation -
Last update: Kubová Petra Ing. (06.03.2019)
Toxicology deals with the interaction of chemicals and the living organism. It is the subject of a summary of basic information on substances that damage the living organism. The subject acquaints with the fate of the substances in the organism and their effects on them and with the way of their toxicity. Several lectures focus on selected inorganic and organic toxic substances and some of their groups. One lecture introduces the prevention of accidents, principles of safe work with toxic substances, describes firefighting and first aid bases. Other lectures briefly describe the environment, the flow of substances and energy in it. The final lectures follow up on the topic of toxic substances in the environment and the problems associated with them.
Aim of the course -
Last update: Kubová Petra Ing. (06.03.2019)

Students will be able to understand:

  • The basic survey about toxicity and negative influence of certain chemical materials on human organism
  • The fate of xenobiotics in organism: entrance, distribution, biotransformation, excretion
  • The safe disposal with chemical substances and principles of first aid during accidents in chemical laboratory
Literature -
Last update: Linhart Igor doc. Ing. CSc. (10.09.2020)

I. Linhart: Basic Terms in Toxicology, Ecology and Ecotoxicology (A bilingual textbook). UCT Press, UCT Prague 2019.


S. Kacew and B.-M-Lee, editors: Lu's Basic Toxicology. Fundamentals, Target Organs, and Risk Assessment. 6th edition, CRC Press 2012; ISBN: 13:978-1-841849539; 10:978-1-841849537); Chapters 1 - 4, 7, 20, 23 and 24.

S. E. Manahan: Toxicological Chemistry and Biochemistry. 3rd edition, Lewis Publishers 2003; ISBN:1-56670-618-1

S.E. Manahan: Fundamentals of Environmental and Toxicological Chemistry. 4th edition, CRC Press 2013;978-1-4665-5316-3

Gilbert Steven G.: A Small Dose of Toxicology, The Health Effects of Common Chemicals, Informa Healthcare USA, 2008, ISBN-10: 0-4153-1168-3, ISBN-13: 978-0-4153-1168-7

Learning resources -
Last update: Kubová Petra Ing. (06.03.2019)

Syllabus -
Last update: Linhart Igor doc. Ing. CSc. (10.09.2020)

1. Introduction, structure of the subject, history of toxicology, ecotoxicology and ecology, concepts and definitions.

2. Substances versus organism - Uptake of xenobiotics, barriers to the uptake, input, absorption, distribution.

3. Biotransformation of xenobiotics, examples of biotransformation reactions of toxic substances.

4. Effects of xenobiotics, types and mechanisms of effects.

5. Assessment of toxicity, literature sources and experimental procedures.

6. Regulation of work with chemicals and MSDS.

7. Toxicity, ecotoxicity and hazards of inorganic substances.

8. Toxicity, ecotoxicity and hazards of organic substances.

9. Abuse of chemical substances: chemical warfare agents and addictive substances.

10. Safety at chemical workplaces (main hazards and ways to minimize the risk).

11. Abiotic and biotic components of the global ecosystem.

12. Biogeochemical cycles and strams energy in nature.

13. Toxic substances in the environment.

14. Current environmental problems.

Registration requirements -
Last update: Kubová Petra Ing. (06.03.2019)


Course completion requirements -
Last update: Kubová Petra Ing. (06.03.2019)

Examination requirements:

The exam starts with written part (student must get min 50 per cent). After successfull written part the oral exam follows. T