SubjectsSubjects(version: 887)
Course, academic year 2020/2021
  
Toxicology and Ecotoxicology II - AB240002
Title: Toxicology and Ecotoxicology II
Guaranteed by: Department of Environmental Chemistry (240)
Actual: from 2020
Semester: summer
Points: summer s.:3
E-Credits: summer s.:3
Examination process: summer s.:
Hours per week, examination: summer s.:2/0 Ex [hours/week]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
Level:  
For type: Bachelor's
Additional information: http://Předmět je vyučován pouze v zimním semestru. Zkoušky se konají u přednášejících.
Old code: ZTOE
Guarantor: Kočí Vladimír doc. Ing. Ph.D., MBA
Mocová Klára Anna Mgr. Ph.D.
This subject contains the following additional online materials
Annotation -
Last update: Kubová Petra Ing. (06.03.2019)
The aim of this course is to explain the principles of toxicity testing mainly as a tool for determination of effects of chemical compounds present in the environment and their impact on different biological species and ecosystem balance. Besides chemical analysis, estimation of ecotoxicity of chemical compounds is an important part of environmental monitoring. Broad spectrum of toxicity tests and their application in waste management or environemntal protection is demonstrated. The student will be guided through the whole process of toxicity testing from sample collection, planning of experimental design to final data interpretation.
Aim of the course -
Last update: Kubová Petra Ing. (06.03.2019)

Students will be able to:

Interpret dose-response curve and other toxicity indexes like EC50, NOEC, LOEC etc.

Describe design of the toxicity test and choose its suitable process.

Propose a suitable test battery for a certain typ of study.

Students will get knowledge of broad variety of toxicity tests at different trophic levels.

Literature -
Last update: Kubová Petra Ing. (06.03.2019)

R: Michael Newman: Fundamentals of Ecotoxicology. Ann Arbor Press, 2010, ISBN 9781420067040.

A: C.H. Walker, S.P. Hopkin: Principles of Ecotoxicology. Taylor & Francis, 1996, ISBN 0-7484-0221-7.

Learning resources -
Last update: Kubová Petra Ing. (06.03.2019)

Electronical text-book

Úvod do toxikologie a ekologie pro chemiky

Horák Josef, Klusoň Petr, Linhart Igor

located: https://e-learning.vscht.cz/

Requirements to the exam -
Last update: Kubová Petra Ing. (06.03.2019)

Examination requirements:

The exam starts with written part (student must get min 50 points from 100). After successful written part the oral exam follows. The exam is focused on topics within the syllabus and the recommended literature.

Syllabus -
Last update: Kubová Petra Ing. (06.03.2019)

1. Relationship between chemical analysis and bioassays in an environmental monitoring. Ecotoxicology and legislation.

2. Toxicity. Design of toxicity testing. Bioconcentration. Bioaccumulation. Biomagnification. Fundamental ecotoxicological indexes and parameters. Dose-response relationship.

3. Relationship between structure and toxicity of compound. Experimental determination of toxicity in laboratory. Bioassays. Classification of toxicity tests.

4. Toxicity testing procedure. Environmental samples. Chemicals testing. Sampling. Pretreatment of samples. Range-finding test. Basic test.

5. Statistical evaluation of toxicity testing. Interpretation of dose-response relationship. Ecotoxicological indexes. Calculations. Multivariate ordination techniques.

6. Biochemical level of toxicity. Molecular effects of toxins. Endocrine disruption.

7. Cells, tissues and organs effects. Sublethal effects to individuals. Acute and chronic lethal effects. Effects on populations, communities and ecosystems.

8. Genotoxicity of chemical compounds in environment. Mutagenesis, carcinogenesis and teratogenesis. Biotests on mutagenity and teratogenity. Teratogenity index.

9. Toxicity testing on plants. Aquatic and terrestrial plants. Description of methods. The use of plant toxicity tests in phytoremediation.

10. Toxicity testing on unicellular organisms. Protozoa. Algal toxicity testing.

11. Toxicity testing on consuments. Aquatic and terrestrial organisms. Determination of toxicity of sediments.

12. Toxicity testing on destruents. Bacterial bioassays. Soil enzymatic activity.

13. Biomarkers of exposition. Biomakers of effect. Bioindicators.

14. Multispecies toxicity tests. Mesocosms, microcosms and in-situ toxicity testing.

Registration requirements -
Last update: Kubová Petra Ing. (06.03.2019)

Toxicology and ecotoxicology I

Course completion requirements -
Last update: Kubová Petra Ing. (06.03.2019)

Examination requirements:

The exam starts with written part (student must get min 50 points from 100). After successful written part the oral exam follows. The exam is focused on topics within the syllabus and the recommended literature.

 
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