SubjectsSubjects(version: 941)
Course, academic year 2019/2020
Biological Process Engineering - AB409009
Title: Biological Process Engineering
Guaranteed by: Department of Chemical Engineering (409)
Faculty: Faculty of Chemical Engineering
Actual: from 2019 to 2020
Semester: winter
Points: winter s.:4
E-Credits: winter s.:4
Examination process: winter s.:
Hours per week, examination: winter s.:2/1, C+Ex [HT]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
Teaching methods: full-time
For type: Bachelor's
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Schreiber Igor prof. Ing. CSc.
Přibyl Michal prof. Ing. Ph.D.
Hasal Pavel prof. Ing. CSc.
Interchangeability : B409009, N409012, S409012
Is interchangeable with: B409009
Examination dates   Schedule   
This subject contains the following additional online materials
Annotation -
Last update: Kubová Petra Ing. (07.02.2018)
The course provides basic overview of quantitative description of processes taking place in enzyme catalysis and in bioreactors. It builds on the principles of chemical engineering, notably on mass and energy balances with the use of kinetic relations for mass transfer and for the biochemical conversion. Student will learn about enzyme processes and bioprocesses but also about unit operations preceding or following the bioreaction.
Aim of the course -
Last update: Schreiber Igor prof. Ing. CSc. (07.06.2023)

Students will be able to:

  • apply chemical engineering methods to biological processes, i.e., make use of balances and kinetic equations,
  • describe kinetics of biochemical reactions and of biomass and microbial product formation,
  • describe quantitatively and design simple bioreactors - stirred batch bioreactor and chemostat.

Literature -
Last update: Kubová Petra Ing. (07.02.2018)

R: Shuler M. L., Kargi F., Bioprocess Engineering. Basic Concepts, Prentice Hall, Upper Saddle River, 2002, 0-13-081908-5

A: Doran P., Bioprocess Engineering Principles, Academic Press, 1995, New York, 9780122208553

Learning resources -
Last update: Kubová Petra Ing. (07.02.2018)

Lecture notes available at

Syllabus -
Last update: Schreiber Igor prof. Ing. CSc. (07.06.2023)

1. Introduction: engineering and biological approach to problem solving (production of penicillin).

2. Basics of cellular biology.

3. Enzymes: classification, molecular structure, general characteristics and properties of enzymes.

4. Enzyme kinetics, kinetic models, determination of kinetic parameters.

5. Immobilization of enzymes, used techniques and methods.

6. Transport processes in systems with immobilized enzymes. Manufacturing of enzymes, applications.

7. Modelling of kinetics for microbial growth and production of metabolites. Stoichiometry.

8. Effect of cultivation conditions on growth kinetics of microbial cells.

9. Cellular growth and production of metabolites in batch cultures.

10. Cellular growth and production of metabolites in continuous cultures.

11. Fermentors, selection of cultivation method, batch and continuous bioreactors.

12. Modelling of bioreactors. Oxygen transport from gas to cells.

13. Choice of bioreactor, scale-up criteria, operation and control of bioreactors.

14. Aeration, sterilization.

Registration requirements -
Last update: Kubová Petra Ing. (07.02.2018)

Unit operations of Chemical Engineering I

Course completion requirements -
Last update: Schreiber Igor prof. Ing. CSc. (30.05.2019)

Student must pass two tests in the course of semester (minimum 25 points out of 50 for each test).

Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1.5 42
Příprava na zkoušku a její absolvování 1 28
Účast na seminářích 0.5 14
4 / 4 112 / 112
Coursework assessment
Form Significance
Continuous assessment of study performance and course -credit tests 50
Oral examination 50