SubjectsSubjects(version: 894)
Course, academic year 2021/2022
  
Supramolecular Chemistry - AM110002
Title: Supramolecular Chemistry
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2020
Semester: winter
Points: winter s.:4
E-Credits: winter s.:4
Examination process: winter s.:
Hours per week, examination: winter s.:2/1 C+Ex [hours/week]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
Level:  
For type: Master's (post-Bachelor)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Lhoták Pavel prof. Ing. CSc.
Interchangeability : N110010
Annotation -
Last update: Kubová Petra Ing. (01.11.2019)
SUPRAMOLECULAR CHEMISTRY is one of the most important innovations in inorganic/organic chemistry. Classical chemistry is based on the concept of covalent bonds which hold together the millions of currently known compounds. On the other hand, there are many processes in the Nature (e.g. enzyme-substrate interaction, immune response, complex formation, DNA replication etc.) which are enabled by the existence of intermolecular recognition based on the non-covalent interactions. These interactions, albeit much weaker that the covalent bonds, are responsible for reversibility of living processes in organisms, which is a fundamental prerequisite for function of living matter. As the direct study of non-covalent interactions in living organisms is too complicated, many simpler systems have been developed to mimic the biological functions on synthetic models. SUPRAMOLECULAR CHEMISTRY is highly interdisciplinary science dealing with study of basic principles of non-covalent interactions and their use in the design of artificial molecules capable of some function on molecular level - selective complexation, construction of receptors, self-assembly, molecular recognition etc.
Aim of the course -
Last update: Kubová Petra Ing. (01.11.2019)

Students will be able to:

design the structure of artificial receptor for the complexation of cation or anion

select suitable analytical method for the study of the structure of the complex

suggest suitable analytical/spectroscopic methods for the measuring of the complexation constants and thermodynamic parameters for selected host-guest processes

apply the principals of "self-assembly" for the synthesis of topological isomers

use the principals of supramolecular chemistry in the advanced organic synthesis

Literature -
Last update: Lhoták Pavel prof. Ing. CSc. (01.11.2019)

R: Jonathan W. Steed, Jerry L. Atwood: Supramolecular Chemistry, 2nd Edition, Wiley 2009. 9780470512340

A: Beer P. D., Gale P. A., Smith D. K.: Supramolecular Chemistry, Oxford Chemistry Primers, Oxford University Press 1999. 0198504470

A: Diderich F., Stang P. J., Tykwinski R. R. (Eds.): Modern Supramolecular Chemistry, Wiley 2008, ISBN: 978-3-527-31826-1.

Learning resources -
Last update: Kubová Petra Ing. (01.11.2019)

Electronic materials available at the lecturer

Syllabus -
Last update: Kubová Petra Ing. (01.11.2019)

1. What is supramolecular chemistry? Introduction and basic definitions. Chemistry of crownethers - complexation of cationts

2. Noncovalent intermolecular interactions

3. Anion complexation

4. Binding of neutral molecules, chiral recognition

5. Modular approach - the coordination chemistry of bipyridines

6. Calix[n]arenes and related macrocycles

7. Cyclodextrins, cucurbiturils, cyclotriveratrylenes

8. Chemistry of fullerenes, carbon nanotubes and other carbon allotropes

9. Dendrimers

10. The evaluation of the complexation ability - complexation constants

11. Self-assembly

12. Topological isomers (rotaxanes, catenanes, knotanes), nanomachines

13. Liquid crystals

14. Surfactants and interfacial ordering

Registration requirements -
Last update: Kubová Petra Ing. (01.11.2019)

No.

Course completion requirements -
Last update: Kubová Petra Ing. (01.11.2019)

The subject is completed by the written and oral examination. A student is qualified for a final exam after obtaining credit and after giving 10 min presentation on a selected topic.

 
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