SubjectsSubjects(version: 954)
Course, academic year 2019/2020
Transition Metals in Organic Synthesis - AM110005
Title: Transition Metals in Organic Synthesis
Guaranteed by: Department of Organic Chemistry (110)
Faculty: Faculty of Chemical Technology
Actual: from 2019
Semester: winter
Points: winter s.:6
E-Credits: winter s.:6
Examination process: winter s.:
Hours per week, examination: winter s.:3/1, Ex [HT]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Dvořák Dalimil prof. Ing. CSc.
Tobrman Tomáš doc. Ing. Ph.D.
Examination dates   Schedule   
Reactions based on the chemistry of transition metals play an important role both in the chemical industry and in the organic synthesis. This course is divided into two parts. In the first part the students familiarize themselves with basic principles of the chemistry of transition metals, with the reactions in coordination sphere and with chemical properties of common ligands. The second part deals with an application of this chemistry in some important industrial processes and especially in the organic synthesis.
Last update: Kundrát Ondřej (24.01.2018)

A: L. S. Hegedus: Transition Metals in the Synthesis of Complex Organic Molecules (University Science Books, Sausalito, California, 1999), 1891389041

A: Robert H. Crabtree: The Organometallic Chemistry of the Transition Metals, 2014, John Wiley & Sons, Inc., DOI:10.1002/9781118788301

R: Christoph Elschenbroich: Organometallics, 2016, John Wiley & Sons, Inc., ISBN: 978-3-527-80516-7

R: Organotransition Metal Chemistry: From Bonding to Catalysis, 2010, University Science Books, U.S. ISBN: 189138953X

Last update: Kubová Petra (09.01.2020)
Syllabus -

1. Formalism (oxidation state, d-electron configuration, 18-electron rule).

2. Basic types of ligands (s-complexes).

3. Basic types of ligands (p-complexes).

4. Reactions in coordination sphere of transition metals (ligand substitution, oxidative addition, reductive elimination, insertion, transmetallation).

5. Nucleophilic attack on ligands coordinated to transition metals.

6. Electrophilic attack on ligands coordinated to transition metals.

7. Homogeneous catalytic reactions (hydrogenation, hydrosilation, hydrocyanation, alkene and alkyne polymerisation, carbonylation reactions).

8. Synthetic applications of transition metal hydrides, organocuprates.

9. Synthetic applications of complexes from insertion of alkenes and alkynes.

10. Synthetic applications of complexes from oxidative addition followed with insertion of alkene, alkyne and carbon monoxide (cross coupling, Heck reaction).

11. Synthetic applications of transition metal carbonyl complexes.

12. Synthetic applications of transition metal carbene complexes (reactions of nucleophilic and electrophilic carbenes, alkene metathesis, metal-catalysed decomposition of diazo compounds).

13. Synthetic applications of h3-allyl transition metal complexes.

14. Synthetic applications of transition metal h6-arene complexes (Cr(CO)3 and FeCp+ complexes).

Last update: Kundrát Ondřej (15.02.2018)
Registration requirements

Organic Synthesis, Organic Reaction Mechanisms

Last update: Kundrát Ondřej (15.02.2018)
Course completion requirements

Successful passing of two seminar tests and oral exam.

Last update: Kundrát Ondřej (16.02.2018)
Teaching methods
Activity Credits Hours
Účast na přednáškách 1.5 42
Příprava na zkoušku a její absolvování 4 112
Účast na seminářích 0.5 14
6 / 6 168 / 168
Coursework assessment
Form Significance
Continuous assessment of study performance and course -credit tests 50
Oral examination 50