SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Specialization Laboratory Course – Chemistry - AM110019
Title: Specialization Laboratory Course – Chemistry
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2019
Semester: winter
Points: winter s.:7
E-Credits: winter s.:7
Examination process: winter s.:
Hours per week, examination: winter s.:0/10 MC [hours/week]
Capacity: unknown / 10 (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
Level:  
For type: Master's (post-Bachelor)
Additional information: http://Předmět je vyučován jen v ZS
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Rybáčková Markéta Ing. Ph.D.
Interchangeability : N110017
Annotation -
Last update: Rybáčková Markéta Ing. Ph.D. (31.07.2019)
The aim of the subject is to acquire both theoretical and experimental knowledge of modern laboratory techniques. Among the performed experiments are cross-coupling reactions, photochemical reactions and other reactions that require handling of organometallic and hydride reagents, working under inert atmosphere using inert lines and septum techniques, working in a glovebox, working at low temperatures and with low-boiling liquids. The products obtained will be isolated by advanced separation techniques (vacuum distillation, crystallization and column chromatography) and their structure and purity will be determined by selected analytical methods (NMR spectroscopy, TLC, UV/VIS spectroscopy). Significant part of the course is devoted to the work on research project in the laboratory of student's tutor.
Aim of the course -
Last update: Rybáčková Markéta Ing. Ph.D. (06.08.2019)

Students will be able to:

work under inert atmosphere using an inert line and septum techniques

work at low temperatures

work in a glovebox

work with low-boiling liquids

work with organometallic and hydride reagents

measure UV spectra and analyse a reaction mixture by HPLC

Literature -
Last update: Rybáčková Markéta Ing. Ph.D. (01.11.2019)

The literature is determined individually for each student by his or her supervisor.

Learning resources -
Last update: Kubová Petra Ing. (15.01.2018)

Printed experiment details

Teaching methods -
Last update: Rybáčková Markéta Ing. Ph.D. (06.08.2019)

Students will attend a laboratory technique course (1st - 4th week of semester, entry 1-8 according to syllabus). Further work will be carried out in specialized laboratories (5th – 14th week of semester). Organization of specialized laboratories will be settled with the student's supervisor.

Syllabus -
Last update: Rybáčková Markéta Ing. Ph.D. (06.08.2019)

1. Determination of unknown concentration of butyllithium solution – working under inert atmosphere using inert lines and septum techniques.

2. Birch reduction of o-xylene – working with low-boiling liquids, working at low temperature, determination of reaction conversion by NMR spectroscopy.

3. Reduction of a carboxylic acid ester – working with hydride reagents under inert atmosphere, crystallization, determination of product purity by NMR spectroscopy.

4. Acylation of cyclohexanone - utilization of enamines in organic synthesis, working with Dean-Stark apparatus, vacuum distillation.

5. Horner-Wadsworth-Emmons reaction – working with sodium hydride under inert atmosphere, crystallization, determination of product purity by NMR spectroscopy.

6. Negishi cross-coupling – working with organozinc reagents under inert atmosphere, column chromatography.

7. Photochemical oxidation of sulfides to sulfoxides – measurement of UV spectra, calculation of extinction coefficient, weighing on an analytical balance, analysis of the reaction mixture by HPLC.

8. Ring-closing metathesis – working in a glovebox, kinetic study using NMR spectroscopy.

9. Research project in a specialized laboratory.

Registration requirements -
Last update: Rybáčková Markéta Ing. Ph.D. (25.02.2018)

No.

Course completion requirements -
Last update: Rybáčková Markéta Ing. Ph.D. (25.02.2018)

To pass the subject, it is compulsory to defend a project given by the lecturer.

Teaching methods
Activity Credits Hours
Účast v laboratořích (na exkurzi nebo praxi) 5 140
Obhajoba individuálního projektu 0,1 2
Práce na individuálním projektu 1,9 54
7 / 7 196 / 196
Coursework assessment
Form Significance
Regular attendance 20
Report from individual projects 20
Defense of an individual project 60

 
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