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Last update: Rybáčková Markéta Ing. Ph.D. (31.07.2019)
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Last update: Rybáčková Markéta Ing. Ph.D. (06.08.2019)
Students will be able to: work under inert atmosphere using an inert line and septum techniques work at low temperatures work in a glovebox work with low-boiling liquids work with organometallic and hydride reagents measure UV spectra and analyse a reaction mixture by HPLC |
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Last update: Rybáčková Markéta Ing. Ph.D. (01.11.2019)
The literature is determined individually for each student by his or her supervisor. |
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Last update: Kubová Petra Ing. (15.01.2018)
Printed experiment details |
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Last update: Rybáčková Markéta Ing. Ph.D. (06.08.2019)
Students will attend a laboratory technique course (1st - 4th week of semester, entry 1-8 according to syllabus). Further work will be carried out in specialized laboratories (5th – 14th week of semester). Organization of specialized laboratories will be settled with the student's supervisor. |
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Last update: Rybáčková Markéta Ing. Ph.D. (06.08.2019)
1. Determination of unknown concentration of butyllithium solution – working under inert atmosphere using inert lines and septum techniques. 2. Birch reduction of o-xylene – working with low-boiling liquids, working at low temperature, determination of reaction conversion by NMR spectroscopy. 3. Reduction of a carboxylic acid ester – working with hydride reagents under inert atmosphere, crystallization, determination of product purity by NMR spectroscopy. 4. Acylation of cyclohexanone - utilization of enamines in organic synthesis, working with Dean-Stark apparatus, vacuum distillation. 5. Horner-Wadsworth-Emmons reaction – working with sodium hydride under inert atmosphere, crystallization, determination of product purity by NMR spectroscopy. 6. Negishi cross-coupling – working with organozinc reagents under inert atmosphere, column chromatography. 7. Photochemical oxidation of sulfides to sulfoxides – measurement of UV spectra, calculation of extinction coefficient, weighing on an analytical balance, analysis of the reaction mixture by HPLC. 8. Ring-closing metathesis – working in a glovebox, kinetic study using NMR spectroscopy. 9. Research project in a specialized laboratory. |
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Last update: Rybáčková Markéta Ing. Ph.D. (25.02.2018)
No. |
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Last update: Rybáčková Markéta Ing. Ph.D. (25.02.2018)
To pass the subject, it is compulsory to defend a project given by the lecturer. |
Teaching methods | ||||
Activity | Credits | Hours | ||
Účast v laboratořích (na exkurzi nebo praxi) | 5 | 140 | ||
Obhajoba individuálního projektu | 0.1 | 2 | ||
Práce na individuálním projektu | 1.9 | 54 | ||
7 / 7 | 196 / 196 |