Principles of Drug Discovery - AM110023
Title: Principles of Drug Discovery
Guaranteed by: Department of Organic Chemistry (110)
Faculty: Faculty of Chemical Technology
Actual: from 2023
Semester: summer
Points: summer s.:4
E-Credits: summer s.:4
Examination process: summer s.:
Hours per week, examination: summer s.:2/1, C+Ex [HT]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Level:  
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Brancale Andrea prof. Ph.D.
Examination dates   
Annotation
The course will cover the main aspects of Drug Design and Discovery, with a more particular emphasis on the medicinal chemistry methods and techniques used in this field. Some of the biological aspects, essential to the overall understanding of the topic, will also be covered.
Last update: Cibulka Radek (22.12.2023)
Aim of the course -

Students will be able to:

understand approaches to suggest suitable target

understand principles of basic computational approaches for drug design

understand approaches to develop leading structure

know modern approaches for drug discovery.

Last update: Cibulka Radek (22.12.2023)
Course completion requirements -

It is compulsory to pass written examination test.

Last update: Cibulková Jana (03.12.2023)
Literature -

R:K. Stromgaard, P. Krogsgaard-Larsen, U. Madsen (Eds.): Textbook of Drug Design and Discovery, CRC Press, 5th Edition 2016; ISBN 9781032339948

R:R. B. Silverman, M. W. Holladay: The Organic Chemistry of Drug Design and Drug Action, Academic Press 2014; ISBN 978-0-12-382030-3

A: C. Rostron: Drug Design and Development, Oxford 2020; ISBN: 9780198749318

Last update: Cibulka Radek (22.12.2023)
Syllabus -

1. The Drug Design and Discovery process

2. Selecting the right target

3. How drugs work

4. Computer-aided drug design I: Structure-Based Drug Design

5. Computer-aided drug design I: Ligand-Based Drug Design

6. Natural compounds in Drug Discovery

7. Fragment-Based Drug Design

8. Hit discovery and lead optimisation I: Structure-Activity Relationships

9. Hit discovery and lead optimisation II: Hit-to-Lead

10. Hit discovery and lead optimisation III: Lead Optimisation

11. Prodrugs

12. Recent advances in Drug Design and Medicinal Chemistry

13. Drugs and their therapeutic landscape

14. Decision making in Drug Discovery

Last update: Cibulka Radek (22.12.2023)
Learning resources -

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Last update: Cibulka Radek (22.12.2023)