SubjectsSubjects(version: 902)
Course, academic year 2021/2022
Bioorganic Chemistry - AP110009
Title: Bioorganic Chemistry
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2019
Semester: winter
Points: winter s.:0
E-Credits: winter s.:0
Examination process: winter s.:
Hours per week, examination: winter s.:3/0 [hours/week]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
For type: doctoral
Note: course is intended for doctoral students only
can be fulfilled in the future
Guarantor: Hocek Michal prof. Ing. DSc.
Ménová Petra Ing. Ph.D.
Interchangeability : D110016, P110009
Annotation -
Last update: Pátková Vlasta (19.11.2018)
The course of Bioorganic chemistry covers the interdisciplinary area at the interface between organic chemistry and biochemistry or biology. It combines and compares molecular principles of structures of functions of biomolecules, molecular principles of biological and biochemical processes, chemical syntheses and biosyntheses of biomolecules and biomacromolecules and bioconjugations, use of biocatalysis in organic synthesis, and the area of chemical biology (the use of chemical means and approaches for the study of biological processes).
Aim of the course -
Last update: Pátková Vlasta (19.11.2018)

Students will be able to:

advanced understanding of the structure and function of biomolecules

know molecular principles and reaction mechanisms of biological and biochemical processes

advanced chemical syntheses of biomolecules and bioconjugates

principles of chemical biology

applications of biocatalysis in chemistry

Literature -
Last update: Pátková Vlasta (19.11.2018)

R: Van Vranken D., Weiss G. A.: Introduction to Bioorganic Chemistry and Chemical Biology, Taylor & Francis Group, 2012. 9780815342144

Learning resources -
Last update: Pátková Vlasta (19.11.2018)

Available from the lecturer (copies of all presentations on CD)

Syllabus -
Last update: Pátková Vlasta (19.11.2018)

1.Introduction: principles of molecular interactions in chemistry and biology.

2.Structure and functions of nucleic acids: types of primary and secondary structures of DNA and RNA, genetic information, other functions of RNA, complexes of nucleic acids with biomolecules, DNA damage and repair.

3.Biosynthesis and metabolism of nucleic acids and their components: replication of DNA, transcription, RNA interference, CRISPR-CAS, biosynthesis and catabolism of nucleosides and nucleotides.

4.Chemical and enzymatic syntheses of nucleosides, nucleotides and oligonucleotides, biocatalytical synthesis and construction of nucleic acids (primer extension, PCR).

5.Structure and functions of proteins: structures of proteins, isolation and analysis of proteins, structure and function of peptides.

6.Biosynthesis and metabolism of amino acids and proteins, protein engineering, regulation of gene expression

7.Chemical and biotechnological syntheses of peptides and proteins: chemical syntheses of peptides on solid support, recombinant method, native peptide ligations, bioconjugations, combinatorial approaches

8.Enzymes and mechanisms of enzymatic reactions: mechanisms and regulation of enzymatic reactions, catalytical principles.

9.Biocatalysis in organic synthesis: use of enzymes, antibodies and whole microorganisms and cell cultures in organic synthesis and biotechnology

10.Carbohydrates: structure and functions of monosaccharides, oligosaccharides and glycosides, their metabolism and basic principles in chemical syntheses

11.Membranes and regulation processes: structures and functions of biomembranes, transports of ions and molecules, regulation processes, receptors and signal cascades

12.Biosynthesis and metabolism of selected other classes of natural compounds: lipids, terpenoids, alkaloids, polyketides etc.

13.Chemical biology: use of chemical means in studying and modulation of biological processes, construction of artificial bioanalogous systems, principles of in vitro selection.

Course completion requirements -
Last update: Pátková Vlasta (19.11.2018)

It is compulsory to pass written examination test with the result at least 50%.