Students will be able to:

perceive organocatalytic reactions in terms known to you from the previous courses on organic chemistry and biochemistry

recognise and understand the basic organocatalytic reactions

understand the mechanisms of organocatalyzed reactions and to broaden the mechanistic understanding in general organic chemistry.

identify conditions required for catalytic cycles to be efficient.

use organocatalysis for designing key steps in the synthesis of organic molecules.

Studeni budou umět:

chápat organokatalytické reakce v pojmech již známých s předchozích kursů organicke chemie a biochemie

porozumět základním organokatalytickým reakcím

porozumnět mechanismům organokatalytických reakcí a rozšířit si mechanistickě povědomí v obecné organické chemii.

určovat podmínky organokatalytických reakcí tak, aby katalytické cykly probíhaly úspěšně.

používat organokatalýzu pro navrhování klíčových kroků v syntéze organických molekul.

R: P. I. Dalko (Ed.): Enantioselective Organocatalysis - Reactions and Experimental Procedures; Wiley-VCH, Weinheim, 2007.

A: P. I. Dalko (Ed.): Comprehensive Enantioselective Organocatalysis - Catalysts, Reactions, and Applications, Vol. 1-3; Wiley-VCH, Weinheim, 2013.

A: R. Rios-Torres (Ed.): Stereoselective Organocatalysis; Wiley, Hoboken, USA, 2013

Z: P. I. Dalko (Ed.): Enantioselective Organocatalysis - Reactions and Experimental Procedures; Wiley-VCH, Weinheim, 2007.

D: P. I. Dalko (Ed.): Comprehensive Enantioselective Organocatalysis - Catalysts, Reactions, and Applications, Vol. 1-3; Wiley-VCH, Weinheim, 2013.

D: R. Rios-Torres (Ed.): Stereoselective Organocatalysis; Wiley, Hoboken, USA, 2013

http://en.wikipedia.org/wiki/Organocatalysis

http://en.wikipedia.org/wiki/Organocatalysis

1. Introduction.

2. Catalysis via Enamines; Aldol reactions, Mannich reactions,α-Heteroatom Functionalization, Michael Additions.

3. Catalysis via Iminium Ions; Cycloadditions, Michael additions, Epoxidations.

4. Brønsted Acids as Catalysts; Michael addition, Hydrocyanation, Mannich reaction, Aza-Henry reaction, Aza-Friedel-Crafts reaction, Pictet-Spengler Reaction, Transfer Hydrogenation, Morita-Baylis-Hillman Reaction, Diels-Alder Reaction.

5. Lewis Bases as Catalysts; Allylation of Aldehydes, Aldol-Type Reactions, Hydrocyanation, Hydrosilylation, Reduction of Imines, Reduction of Ketones.

6. Epoxidation.

It is compulsory to pass written examination test.

Úspěšné absolvování zkouškové písemky.