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Last update: Pátková Vlasta (08.06.2018)
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Last update: Pátková Vlasta (08.06.2018)
Students will be able to:
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Last update: Pátková Vlasta (08.06.2018)
R: Alon U, An introduction to systems biology. Design principles of biological circuits, Chapman & Hall/CRC 2007, ISBN: 978-1584886426 R: Klipp E, Liebermeister W, Wierling C, Kowald A, Lehrach H, Herwig R, Systems Biology: A textbook, Wiley-VCH Verlag 2009, 978-3527318742 |
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Last update: Pátková Vlasta (08.06.2018)
none |
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Last update: Pátková Vlasta (08.06.2018)
1. How cells perceive a world. Regulatory networks. 2. Transcription networks and their properties. Network motifs. 3. Autoregulation: SOS DNA repair system in E. coli. 4. Coherent feed-forward loop: protection against random fluctuations. Arabinosis system in E. coli. 5. Noncoherent feed-forward loop: quick response to the environment change. Galactosis system in E. coli. 6. Regulatory networks in embryonal development: bistable switch. Sonic Hedgehog and the limb development in vertebrae. 7. Neural networks: multilayer perceptron in C. elegans. 8. Other network motifs and global structure of regulatory networks. Project assignment. 9. Robustness of protein circuits: chemotaxion in E. coli. 10. Robustness in embryonal development: body segmentation in D. melanogaster. 11. Kinetic proofreading: antigenu T recognition by the cell. 12. Optimality of gene circuits, relationship with a biological fitness: LacZ protein in E. coli. 13. Optimality of gene circuits, rule of the demand. 14. Project presentations. |
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Last update: Pátková Vlasta (08.06.2018)
Biochemistry, Molecular genetics |
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Last update: Pátková Vlasta (08.06.2018)
Oral exam |