SubjectsSubjects(version: 912)
Course, academic year 2022/2023
Bioengineering - AP319001
Title: Bioengineering
Guaranteed by: Department of Biotechnology (319)
Faculty: Faculty of Food and Biochemical Technology
Actual: from 2019
Semester: both
Points: 0
E-Credits: 0
Examination process:
Hours per week, examination: 3/0, other [HT]
Capacity: winter:unknown / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
Language: English
Teaching methods: full-time
For type: doctoral
Note: course is intended for doctoral students only
can be fulfilled in the future
you can enroll for the course in winter and in summer semester
Guarantor: Halecký Martin doc. Ing. Ph.D.
Interchangeability : D319003, P319001
Annotation -
Last update: Pátková Vlasta (15.11.2018)
The characterization of biological processes catalyzed by enzymes or microbial cells is carried out by models including kinetic and mass balance equations. This course is therefore focused on creating mass and energy balances and their application in mathematical models describing the studied systems. These models of biological systems will be used to predict the behaviour of systems im limit cases and in scale-up (down) processes.
Aim of the course -
Last update: Pátková Vlasta (15.11.2018)

Student will be able to:

Independently carry out mass balances of different biotechnological processes.

Extend the mass balances with kinetic equations describing the dynamic aspects of the system.

Estimate the key process parameters and by using them describe the scale-up (down) of bioprocesses.

Literature -
Last update: Pátková Vlasta (15.11.2018)

R - Lecture presentations

R - Zlokarnik M. Scale-up in Chemical Engineering, Wiley-VCH, 2002, ISBN: 3-527-30266-2

R - Levin M. (ed) Pharmaceutical Process Scale-up, Marcel Dekker Inc., 2001, ISBN: 0-8247-0625-0

A - Reisman H.B. Problems in scale-up of biotechnology production process, Critical Reviews in Biotechnology 13(3):195-253, 1993

Learning resources -
Last update: Pátková Vlasta (15.11.2018)

Teaching methods -
Last update: Pátková Vlasta (15.11.2018)

Lectures of lecturers, presentation of students on their chosen and processed topic including self-study.

Requirements to the exam -
Last update: Pátková Vlasta (15.11.2018)


Syllabus -
Last update: Pátková Vlasta (15.11.2018)

The structure of bioprocesses, overview of equipment and unit operations.

The methods and procedure of biological processes modeling.

Mass and energy balancess.

Kinetics of enzymatic reactions and microbial growth.

Scale-up and scale-down of bioprocesses.

Criteria of scale-up, principles of similarity (geometric, kinetic, dynamic)

Dimensional analysis.

Entry requirements -
Last update: Pátková Vlasta (15.11.2018)


Registration requirements -
Last update: Pátková Vlasta (15.11.2018)


Course completion requirements -
Last update: Pátková Vlasta (15.11.2018)

Assessment of student presentations. Exam.