SubjectsSubjects(version: 949)
Course, academic year 2021/2022
Toxicology and Ecotoxicology I - B240001
Title: Toxikologie a ekotoxikologie I
Guaranteed by: Department of Environmental Chemistry (240)
Faculty: Faculty of Environmental Technology
Actual: from 2021 to 2021
Semester: both
Points: 3
E-Credits: 3
Examination process:
Hours per week, examination: 2/0, Ex [HT]
Capacity: winter:unlimited / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
For type: Bachelor's
Additional information: http://Předmět je vyučován pouze v zimním semestru. Zkoušky se konají u přednášejících.
Old code: ZTOE
Note: you can enroll for the course in winter and in summer semester
Guarantor: Kočí Vladimír prof. Ing. Ph.D., MBA
McGachy Lenka Ing. Ph.D.
Interchangeability : N111009, N240011, Z240011
This subject contains the following additional online materials
Annotation -
Last update: Kočí Vladimír prof. Ing. Ph.D., MBA (10.01.2018)
Toxicology deals with the interaction of chemicals and the living organism. It is the subject of a summary of basic information on substances that damage the living organism. The subject acquaints with the fate of the substances in the organism and their effects on them and with the way of their toxicity. Several lectures focus on selected inorganic and organic toxic substances and some of their groups. One lecture introduces the prevention of accidents, principles of safe work with toxic substances, describes firefighting and first aid bases. Other lectures briefly describe the environment, the flow of substances and energy in it. The final lectures follow up on the topic of toxic substances in the environment and the problems associated with them.
Aim of the course -
Last update: Kočí Vladimír prof. Ing. Ph.D., MBA (10.01.2018)

Students will be able to understand:

  • The basic survey about toxicity and negative influence of certain chemical materials on human organism
  • The fate of xenobiotics in organism: entrance, distribution, biotransformation, excretion
  • The safe disposal with chemical substances and principles of first aid during accidents in chemical laboratory
Literature -
Last update: Linhart Igor doc. Ing. CSc. (10.09.2020)

I. Linhart: Basic Terms in Toxicology, Ecology and Ecotoxicology (A bilingual textbook). UCT Press, UCT Prague 2019.


S. Kacew and B.-M-Lee, editors: Lu's Basic Toxicology. Fundamentals, Target Organs, and Risk Assessment. 6th edition, CRC Press 2012; ISBN: 13:978-1-841849539; 10:978-1-841849537); Chapters 1 - 4, 7, 20, 23 and 24.

S. E. Manahan: Toxicological Chemistry and Biochemistry. 3rd edition, Lewis Publishers 2003; ISBN:1-56670-618-1

S.E. Manahan: Fundamentals of Environmental and Toxicological Chemistry. 4th edition, CRC Press 2013;978-1-4665-5316-3

Gilbert Steven G.: A Small Dose of Toxicology, The Health Effects of Common Chemicals, Informa Healthcare USA, 2008, ISBN-10: 0-4153-1168-3, ISBN-13: 978-0-4153-1168-7

Learning resources -
Last update: Kočí Vladimír prof. Ing. Ph.D., MBA (10.01.2018)

Syllabus -
Last update: Linhart Igor doc. Ing. CSc. (10.09.2020)

1. Introduction, structure of the subject, history of toxicology, ecotoxicology and ecology, concepts and definitions.

2. Substances versus organism - uptake of substances, barriers, absorption, distribution.

3. Biotransformation of substances, examples of biotransformation reactions of toxic substances.

4. Effects of substances, types and mechanisms of effects.

5. Investigation of toxicity, literature sources and experimental procedures.

6. Regulation of work with chemicals and SDS.

7. Toxicity, ecotoxicity and risks of inorganic substances.

8. Toxicity, ecotoxicity and risks of organic substances.

9. Abuse of chemical substances: chemical weapons and addictive substances.

10. Safety in chemical workplaces (main hazards, ways to minimize the risk).

11. Abiotic and biotic parts of the global ecosystem.

12. Biogeochemical cycles and streams of energy in nature.

13. Toxic substances in the environment.

14. Current environmental problems.

Registration requirements -
Last update: Kočí Vladimír prof. Ing. Ph.D., MBA (10.01.2018)


Course completion requirements -
Last update: McGachy Lenka Ing. Ph.D. (06.09.2023)

Written exam

• students enrol in SIS

• the test is set and marked by the course teacher, or a person authorised by the course teacher

• to complete the course students, have to pass written exam with minimum score of 50%

Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na zkoušku a její absolvování 2 56
3 / 3 84 / 84