SubjectsSubjects(version: 955)
Course, academic year 2023/2024
Special analytical methods for pharmaceuticals - B402009
Title: Speciální analytické metody pro léčiva
Guaranteed by: Department of Analytical Chemistry (402)
Faculty: Faculty of Chemical Engineering
Actual: from 2021
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: 16 / unknown (unknown)
Min. number of students: unlimited
State of the course: taught
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Additional information:
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Řezanka Pavel doc. RNDr. Ing. Ph.D.
Interchangeability : N402061
This subject contains the following additional online materials
Annotation -
This course is focused on the methods used in the analysis of drugs, especially on methods that are not discussed in other subjects (Physical Chemistry and Analytical Chemistry). The principles of the mentioned methods will be described, including their practical applications and samples of sample analysis records. Emphasis will be placed on the distinction between polymorphs and amorphous, as well as individual polymorphs from each other. At the end of the subject, the legislation related to polymorphic and amorphous states from the point of view of patent protection will be mentioned, as well as the currently used methods of searching for solid forms of active pharmaceutical ingredients.
Last update: Řezanka Pavel (12.09.2023)
Aim of the course -

1. The graduate will acquire knowledge of analytical methods used for drug analysis.

2. The graduate will acquire knowledge of legislation related to polymorphic and amorphous forms of drugs

3. The graduate will be able to choose an analytical method appropriate for the studied problem.

4. The graduate will be able to evaluate and interpret records obtained by measuring drug samples using the discussed analytical methods.

Last update: Řezanka Pavel (12.09.2023)
Literature -

A: Zheng J. (Editor), Formulation and Analytical Development for Low-Dose Oral Drug Products, Wiley, 2009, ISBN: 978-0-470-05609-7.

A: Gunzler H., Williams A. (Editors), Handbook of Analytical Techniques, 2 Volume Set, Wiley, 2001, ISBN: 978-3-527-30165-2.

A: Gough T. A., The Analysis of Drugs of Abuse, Wiley, 1999, ISBN: 978-0-471-92267-4.

Last update: Řezanka Pavel (12.09.2023)
Learning resources -

Materials in the relevant subject on e-learning:

1. Presentation (pptx)

2. Commented videos

3. Materials for individual activities

Last update: Řezanka Pavel (12.09.2023)
Teaching methods -

Teaching takes place using the flipped class method with an emphasis on activating elements during the lesson. Comprehension of the topics discussed is verified by continuous tests. Emphasis is placed on both soft and hard skills.

Last update: Řezanka Pavel (12.09.2023)
Requirements to the exam -

The course ends with a written exam.

1. The written exam lasts 30 minutes.

2. The student registers for the exam through the Study Information System (SIS) and it is the student's responsibility to register by the deadline specified here. Deregistration from the exam is possible until the date specified in the SIS, later only with the examiner, and only for serious reasons. In case of non-participation and non-registration, the term is forfeited and is classified as "F".

3. If you arrive late for the written exam, the examiner may allow you to write the paper, but the missed time will not be compensated.

4. During the exam, it is not allowed to leave the room and use unauthorized aids, including telecommunication devices.

5. The place and time of publication of the results of the written exam will be announced during the written exam. The examiner will determine when and where the written work will be available for inspection. If the student does not appear on this date, he gives up the opportunity to view the assessment.

6. The student has the right to a maximum of two correction dates.

Last update: Řezanka Pavel (12.09.2023)
Syllabus -

1. Introduction to the solid state

2. Thermal analysis I

3. Thermal analysis II

4. Thermal analysis III

5. Isothermal analysis

6. Calorimetric methods

7. Surface analysis I

8. Surface analysis II

9. Particle analysis I

10. Particle analysis II

11. Particle analysis III

12. Prediction of polymorphs

13. Patenting

14. Selection of solid forms

Last update: Řezanka Pavel (12.09.2023)
Entry requirements -

Physical Chemistry

Analytical Chemistry

Last update: Řezanka Pavel (12.09.2023)
Registration requirements -

Physical Chemistry

Analytical Chemistry

Last update: Řezanka Pavel (12.09.2023)
Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1 28
Příprava na zkoušku a její absolvování 1 28
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