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Hyphenated methods applied for the analysis of drugs are discussed. Principles, advantages vs disadvantages, and typical applications are provided.
Last update: Kubová Petra (16.01.2018)
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A: Holčapek M. - (Editor) - Spojení vysokoúčinné kapalinové chromatografie a hmotnostní spektrometrie (HPLC/MS), Univerzita Pardubice, 2001, ISBN: 80-7194-390-8. A: Štulík K. - (Editor), Analytické separační metody, Univerzita Karlova v Praze - Nakladatelství Karolinum, 2005, ISBN: 80-246-0852-9. A: Gross J.H. - (Editor), Mass Spectrometry - A textbook, Springer, 2004, ISBN:3-540-40739-1. A: Albert K. - (Editor), On-Line LC-NMR and Related Techniques, Wiley, 2002, ISBN: 978-0-471-49649-6. A: Watson J.K.; Sparkman O.D. - (Editors), Introduction to Mass Spectrometry, Wiley, 2007, ISBN:978-0-470-51634-8. A: Niessen, W.M.A.; Liquid Chromatography - Mass Spectrometry; Marcel Dekker, 1999, ISBN: 0-8247-1936-0. Last update: Kubová Petra (16.01.2018)
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Presentations. Last update: Kubová Petra (16.01.2018)
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1. General principles of hyphenated methods, basic terms of mass spectrometry (MS). 2. Ion sources for MS. 3. MS Analysers - 1. 4. MS Analysers - 2. 5. Ion detectros. 6. Vacuum systems. 7. HPLC-MS; principles and applications. 8. HPLC-MS; basic principles of mass spectra interpretation. 9. GC-MS; principles and applications. 10. Interpretation of EI spectra - 1. 11. Interpretation of EI spectra - 2. 12. Interpretation of EI spectra - 3. 13. Technique GC x GC. 14. Technique LC x LC. Last update: Kubová Petra (16.01.2018)
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Electronic version of the presentations available to students. Last update: Kubová Petra (16.01.2018)
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Students will be able: to propose suitable technique to solve a specific analytical problem. to consider advantages and disadvantages of the individual proposed solutions. to interpret EI MS spectra on a basic level. Last update: Kubová Petra (16.01.2018)
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None. Last update: Kubová Petra (16.01.2018)
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Teaching methods | ||||
Activity | Credits | Hours | ||
Účast na přednáškách | 1 | 28 | ||
Příprava na zkoušku a její absolvování | 2 | 56 | ||
3 / 3 | 84 / 84 |