|
|
|
||
Last update: Cibulka Radek prof. Ing. Ph.D. (23.06.2018)
|
|
||
Last update: Cibulka Radek prof. Ing. Ph.D. (23.06.2018)
Students will be able to: Use nomenclature of retrosynthetic analysis Plan synthesis of multifunctional compounds Apply algoritms of retrosynthetic analysis to design synthesis of complex compounds Evaluate the best synthetic pathway |
|
||
Last update: Cibulka Radek prof. Ing. Ph.D. (23.06.2018)
R: Warren S., Wyatt P.: Organic synthesis - The disconnection approach, 2nd Edition, John Wiley, 2008, 9780470712368 R: Warren S., Wyatt P.: Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition, John Wiley, 2009, 9780470712276 A: Wyatt P., Warren S.: Organic Synthesis - Strategy and Control, John Wiley, 2007, 9780470489405 |
|
||
Last update: Cibulka Radek prof. Ing. Ph.D. (03.04.2014)
http://uoch.vscht.cz/cz/download/synton.pdf |
|
||
Last update: Cibulka Radek prof. Ing. Ph.D. (23.06.2018)
1. The disconnection approach. Basic principles. Transformations. 2. Synthons and their preparation. Umpolung, logical and nonlogical synthons. 3. One group C-X disconnections. 4. Two group C-X disconnections. 5. One group C-C disconnections in oxidation state of alcohols. 6. One group C-C disconnections in oxidation state of ketones. 7. Alkene and alkyne synthesis. Synthesis of biaryls. 8. Two group disconnections - introduction. C-C disconnection in 1,3- and 1,5-difunctionalised compounds. 9. Synthesis of 1,2-, 1,4- and 1,6-difunctionalised compounds. 10. Strategy of ring synthesis. Baldwin's rules. 11. Synthesis of cyclobutane and cyclopentane derivatives. 12. Synthesis of cyclopentane and cyclohexane derivatives and of the compounds with large ring. 13. Heterocyclic compounds - classification. Synthesis of heterocyclic and heteroaromatic compounds. 14. Multistep synthesis of natural compounds. |
|
||
Last update: Cibulka Radek prof. Ing. Ph.D. (23.06.2018)
It is compulsory to prepare project on the synthesis of natural compound, to pass written examination test with the result at least 60%, and finally to pass successfuly the oral examination. |
Coursework assessment | |
Form | Significance |
Examination test | 50 |
Oral examination | 50 |