SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Chemistry of Heterocyclic Compounds - D110012
Title: Chemie heterocyklických sloučenin
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2011
Semester: winter
Points: winter s.:0
E-Credits: winter s.:0
Examination process: winter s.:
Hours per week, examination: winter s.:0/0 other [hours/week]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Note: course is intended for doctoral students only
can be fulfilled in the future
Guarantor: Kozmík Václav Ing. CSc.
Annotation -
Last update: Kozmík Václav Ing. CSc. (11.04.2014)
The Lectures on Chemistry of heterocyclic compounds aim to introduce the preparation and reactivity of various simple heterocyclic compounds to the students. Based on the knowledge of the reactivity of heterocyclic compounds they should be able to design a synthesis of heterocyclic systems with a help of chemical literature and databases.
Aim of the course -
Last update: Kozmík Václav Ing. CSc. (10.04.2014)

Students will be able to:

describe the reactivity of basic heterocycles

depict syntheses of the basic heterocycles

suggest a synthesis of complicated heterocyclic systems using literature

Literature -
Last update: Kozmík Václav Ing. CSc. (10.04.2014)

R: Theophil Eicher, Siegfried Hauptmann: The Chemistry of Heterocycles (Structure, Reactions, Syntheses and Applications), Georg Thieme Verlag Stuttgart, New York 1995, ISBN 0865776253, 9780865776258

A: Alan R. Katritzky, Alexander F. Pozharskii: Handbook of Heterocyclic Chemistry, Second edition 2000, Pergamon 2000,ISBN 0080429890, 9780080429892

Learning resources -
Last update: Kozmík Václav Ing. CSc. (10.04.2014)

Václav Kozmík: Heterocyklické sloučeniny, http://uoch.vscht.cz/cz/download/Heterocyklicke_slouceniny.pdf

Syllabus -
Last update: Kozmík Václav Ing. CSc. (11.04.2014)

1. Trivial and Hantzsch - Widman nomenclature of simle heterocyclus.

2. Nomenclature and numbering of heterocyclic systems. Examples.

3. Synthesis and properties of 3-membered heterocycles.

4. Synthesis and properties of 4-membered heterocycles.

5. Synthesis and properties of 5-membered heterocycles with 1 heteroatoms.

6. Synthesis and properties of 5-membered heterocycles with 2 heteroatoms.

7. Synthesis and properties of 5-membered heterocycles with 3 and more heteroatoms.

8. Synthesis and properties of 6-membered heterocycles with 1 heteroatoms.

9. Synthesis and properties of 6-membered heterocycles with 2 heteroatoms.

10. Synthesis and properties of 6-membered heterocycles with 3 and more heteroatoms.

11. Synthesis and properties of 7 and more membered heterocycles.

12. Generalization of nucleophilic and electrophilic substitutions and metallation reactions.

13. Generalization of addition and cycloaddition reactions.

14. Biological activity of heterocycles.

Course completion requirements -
Last update: Kozmík Václav Ing. CSc. (25.04.2014)

Students have to propose a synthesis of two or three complicated heterocyclic compounds according to the assignment and present and defend it in front of the lecturer and students of this lecture.

Coursework assessment
Form Significance
Defense of an individual project 20
Examination test 50
Oral examination 30

 
VŠCHT Praha