SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Fundamentals of Supramolecular Chemistry - D110020
Title: Základy supramolekulární chemie
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2014
Semester: winter
Points: winter s.:0
E-Credits: winter s.:0
Examination process: winter s.:
Hours per week, examination: winter s.:0/0 other [hours/week]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Note: course is intended for doctoral students only
can be fulfilled in the future
Guarantor: Lhoták Pavel prof. Ing. CSc.
Is interchangeable with: AP110011, P110011
Annotation -
Last update: Lhoták Pavel prof. Ing. CSc. (25.04.2014)
"Fundamentals of Supramolecular Chemistry" is dealing with the study of non-covalent interactions and the description of systems based on such interactions. The most popular families of highly preorganized compounds (crown ethers, calixarenes, cyclodextrins, porphyrins, resorcarenes, cucurbiturils, fullerenes, dendrimers etc.) are introduced within the scope of this subject. These compounds are then used as a starting point for the design of various receptors for the complexation of selected species (ions or neutral molecules) or for the construction of molecules possessing defined functions (nanomachinery). The basic concepts of supramolecular chemistry, such as preorganization, self-assembly, molecular recognition, complexation, host-guest chemistry, template synthesis, mechanically-interlocked molecules, dynamic combinatorial chemistry etc. are discussed as well.
Aim of the course -
Last update: Lhoták Pavel prof. Ing. CSc. (25.04.2014)

Students will be able to:

design and synthesis of artificial receptor for the complexation of cation or anion

select suitable analytical method for the study of the structure of a given complex

suggest suitable analytical/spectroscopic methods for the measuring of the complexation constants and thermodynamic parameters for selected host-guest processes

apply the principals of "self-assembly" for the synthesis of topological isomers

use the principals of supramolecular chemistry in the advanced organic synthesis

Literature -
Last update: Lhoták Pavel prof. Ing. CSc. (25.04.2014)

R: Jonathan W. Steed, Jerry L. Atwood: Supramolecular Chemistry, 2nd Edition, Wiley 2009. 9780470512340

A: Beer P. D., Gale P. A., Smith D. K.: Supramolecular Chemistry, Oxford Chemistry Primers, Oxford University Press 1999. 0198504470

A: Diderich F., Stang P. J., Tykwinski R. R. (Eds.): Modern Supramolecular Chemistry, Wiley 2008, ISBN: 978-3-527-31826-1.

A: Lhoták P., Stibor I.: Molekulární Design; vysokoškolská skripta, vydavatelství VŠCHT Praha, 1997. 8070802952

A: kolektiv autorů: Supramolekulární chemie I, Cyklus Organická Chemie, svazek 29, 2004, ÚOCHB Praha. 8086241211

A: kolektiv autorů: Supramolekulární chemie II, Cyklus Organická Chemie, Svazek. 30, UOCHB AV ČR Praha, 2005. 8086241270

Learning resources -
Last update: Lhoták Pavel prof. Ing. CSc. (25.04.2014)

Electronic materials available at the lecturer.

Lectures and selected texts in pdf format.

Syllabus -
Last update: Lhoták Pavel prof. Ing. CSc. (25.04.2014)

1. What is supramolecular chemistry? Introduction and basic definitions.

2. Ionophores and complexation of cations.

3. Anion complexation, design of receptors.

4. Binding of neutral molecules, chiral recognition

5. Noncovalent intermolecular interactions

6. Modular approach - the coordination chemistry of pyridines and bipyridines.

7. Cyclodextrins, cucurbiturils, cyclotriveratrylenes, cyclophanes.

8. Calix[n]arenes and related macrocycles.

9. Chemistry of dendrimers-structure, properties and applications.

10. Liquid crystals

11. Surfactants and interfacial ordering

12. The evaluation of the complexation constants and thermodynamic parameters.

13. Chemistry of fullerenes, carbon nanotubes and other carbon allotropes.

14. Self-assembly, topological isomers (rotaxanes, catenanes, knotanes), nanomachines.

Course completion requirements -
Last update: Cibulka Radek prof. Ing. Ph.D. (10.05.2014)

PowerPoint presentation on selected topic

Final test

Oral examination

Coursework assessment
Form Significance
Defense of an individual project 10
Examination test 50
Oral examination 40

 
VŠCHT Praha