SubjectsSubjects(version: 877)
Course, academic year 2020/2021
  
Bioinorganic Chemistry - M101006
Title: Bioanorganická chemie
Guaranteed by: Department of Inorganic Chemistry (101)
Actual: from 2020
Semester: winter
Points: winter s.:3
E-Credits: winter s.:3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: Master's (post-Bachelor)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Hoskovcová Irena Ing. CSc.
Interchangeability : N101025
Annotation -
Last update: Pátková Vlasta (10.01.2018)
The course is based on the Coordination chemistry course. It is aimed at the role of metals in both electron and mass transfers in living systems. It describes the behaviour of individual metals focusing on the relationship between their chemical properties and biological activity, toxicity and therapeutic use.
Aim of the course -
Last update: Pátková Vlasta (10.01.2018)

Students will be able to:

Describe the chemical nature of metal biological activity

Describe the role of biogenic metals in metabolism

Explain toxicity or therapeutical use of non-biogenic metals

Evaluate suitable use of analytical methods in order to study metal ions in biological systems

Literature -
Last update: Pátková Vlasta (10.01.2018)

R: R. R. Crichton, Biological Inorganic Chemistry, 2nd ed., Elsevier 2011, ISBN: 978-0-444-53782-9

A: R. M. Roat-Malonee, Bioinorganic Chemistry, Wiley 2002, ISBN 0-471-15976-X

Learning resources -
Last update: Pátková Vlasta (10.01.2018)

http://vydavatelstvi.vscht.cz/knihy/uid_es-002/

http://www.vscht.cz/ach/vyuka-magisterske-koordch.html ¨

Requirements to the exam -
Last update: Pátková Vlasta (10.01.2018)

Students write a test and pass an oral examination.

Syllabus -
Last update: Pátková Vlasta (10.01.2018)

1. Formal oxidation states and coordination stereochemistry of biologically important metals

2. Stability constants, kinetics and reaction mechanisms of metal complexes

3. Metal ions uptake and their transmembrane flow

4. Metal transport and storage in vivo

5. Myoglobin and haemoglobin. Haemerythrin, haemocyanin.

6. Hydrolysis, carboxypeptidase A, phosphates, hydrolyases, aconitase.

7. Cofactores and coenzymes in redox metalloproteins

8. Iron and sulphur containing clusters, haem.

9. Cupper ions and their complexes

10. Molybdenum, cobalamines, nickel-containing coenzymes

11. Electron-transfer in mitochondria

12. Overview of the 1st and 2nd group metals role in biological systems

13. Enzyme activation, complexes with nucleic acids, biominerals, skeleton.

14. Oxygen toxicity, metal toxicity. Coordination compounds in therapy and diagnostics.

Registration requirements -
Last update: Pátková Vlasta (10.01.2018)

General and Inorganic chemistry II, Biochemistry

Course completion requirements -
Last update: Nekvindová Pavla doc. Ing. Ph.D. (16.02.2018)

Students must pass the written as well as oral part of the exam.

Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 0,5 14
Práce na individuálním projektu 0,5 14
Příprava na zkoušku a její absolvování 1 28
3 / 3 84 / 84
 
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