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Last update: Fialová Jana (04.01.2018)
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Last update: Fialová Jana (04.01.2018)
Students will be able to: utilize methods of reduction and oxidation of all kind of organic functional groups introduce and remove various functionalities in organic molecules construct various complex carbon chains utilizng alkalytion and acylation reactions selectively protect functionasl groups in multi-step syntheses design syntheses of organic compounds on intermediate level |
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Last update: Fialová Jana (04.01.2018)
R: Svoboda J.: Organická syntéza I - Transformace funkčních skupin. 80-7080-385-1 A: F. A. Carey, R. J. Sundberg: Advanced Organic Chemistry, 5th Ed., Part B, 2006.978-0-387-68354-6 |
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Last update: Fialová Jana (04.01.2018)
Teaching support to lectures at the lecturer. |
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Last update: Fialová Jana (04.01.2018)
1. Reduction. Catalytic hydrogenation, reduction of multiple bonds. 2. Reduction of functional groups, hydrogenolytic reactions. 3. Oxidation of a nonfunctional and functional carbon atom, hydroxylation, oxidation leading to carbonyl compounds and carboxylic acids. Oxidation of O, N, and S-functional groups, oxidative decarboxylation. 4. Halogenation. Addition and substitution reactions. Substitution of halogenes, O- and N-derivatives. 5. Alkylation a acylation reactions. Nucleophilic substitution, nucleophilic and alkylation reagents, PTC-catalysis. 6. Alkylation of heteroatoma, alkylation of C-acids. Base catalyzed aldolisation reactions. The Wittig and related reactions. 7. Friedel-Crafts alkylation and acylation, halomethylation, formylation. 8. Nitration and nitrosation. Application for the synthesis of nitro and nitroso compounds. Sulfonation of aliphatic and aromatic compounds. 9. Formation and reactivity of diazonium salts. Diazotation, substitution of the diazo group, coupling reactions. 10. Formation of organometallic compounds. 11. Aplication of organometallic compounds. 12. Elimination reactions. Mechanisms, dehydration, deoxygenations, elimination of N-, S-groups, halogens, decarboxylation, extrusion. 13. Functional derivatives of carbonyl and carboxylic group. Acetals, nitrogen derivatives. Formation of functional derivatives of carboxylic acids. 14. Principle of protection in organic synthesis. Protection of OH, CO, NH2 and COOH. |
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Last update: Kundrát Ondřej Ing. Ph.D. (08.01.2018)
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Last update: Kundrát Ondřej Ing. Ph.D. (16.02.2018)
Předmět je zakončen zkouškou, která se skládá z písemné a ústní části. Student může přistoupit ke zkoušce z Organické syntézy poté, co získal zápočet na cvičeních z Organické syntézy. |
Teaching methods | ||||
Activity | Credits | Hours | ||
Účast na přednáškách | 1.5 | 42 | ||
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi | 2.5 | 70 | ||
Příprava na zkoušku a její absolvování | 2 | 56 | ||
Účast na seminářích | 1 | 28 | ||
7 / 7 | 196 / 196 |