SubjectsSubjects(version: 893)
Course, academic year 2021/2022
Organic Reaction Mechanisms - M110006
Title: Mechanismy organických reakcí
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2021 to 2021
Semester: winter
Points: winter s.:5
E-Credits: winter s.:5
Examination process: winter s.:
Hours per week, examination: winter s.:2/2 C+Ex [hours/week]
Capacity: 25 / 25 (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
For type: Master's (post-Bachelor)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Kovaříček Petr Ing. Ph.D.
Interchangeability : N110015
Is interchangeable with: N110015
Examination dates   Schedule   
This subject contains the following additional online materials
Annotation -
Last update: Fialová Jana (04.01.2018)
The course is focused on mechanistic interpretation of reactions and processes in organic chemistry and their application in prediction of reaction parameters, product composition and stereochemistry of synthetically useful organic reactions.
Aim of the course -
Last update: Fialová Jana (04.01.2018)

Students will be able to:

understand the mechanisms of substitution, elimination and addition reactions.

predict the course of reactions.

suggest suitable mechanism of novel organic reaction.

Literature -
Last update: Fialová Jana (04.01.2018)

R: O. Cervinka a kol., Mechanizmy organickych reakci, SNTL/ ALFA, Praha 1981. 0463281

R: Reinhard Bruckner, Advanced Organic Chemistry, Harcourt Academic Press, 2002. 9780121381103

Learning resources -
Last update: Fialová Jana (04.01.2018)

Study materials available on request.

Syllabus -
Last update: Fialová Jana (04.01.2018)

1. General terms. Structural and electronic effects influencing a reaction course. Transition state theory.

2. Electrophilic substitution on sp3 hybridized carbon atom. Molecularity of the chemical reaction. Synthetic use and examples.

3. Nucleophilic substitution on sp3 hybridized carbon atom. Molecularity of chemical the reaction. Synthetic use and examples. Neighboring group participation in the reaction outcome and mechanism. Qualitative and quantitative evaluation of the nucleophiles and leaving groups.

4. Electrophilic aromatic substitution. Molecularity of the chemical reaction. Synthetic use and examples. Evaluation of substituents on aromatic systems and their influence on the reaction course.

5. Nucleophilic aromatic substitution. Meisenheimer complex.

6. Radical substitutions.

7. Eliminations. Zaitsev and Hoffmann rules. Regioselectivity of the reaction.

8. Additions. Steric effects and their influence on the reaction course. Application of the reaction in organic synthesis.

9. Diels- Alder type reaction. Cyclo-additions. Synthetic examples.

10. Nucleophilic additions on polarized bonds. Reaction of carbonyl compounds with organometalic reagents.

11. Oxidations and reductions.

12. Molecular rearrangements. Wagner- Meerwein rearrangements.

13. Photochemical reactions

Registration requirements -
Last update: Kundrát Ondřej Ing. Ph.D. (08.01.2018)


Course completion requirements - Czech
Last update: Kundrát Ondřej Ing. Ph.D. (15.02.2018)

Účast na semestrálních testech a ústní zkouška.

Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0,5 14
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1 28
Příprava na zkoušku a její absolvování 1,5 42
Účast na seminářích 1 28
5 / 5 140 / 140