SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Specialized Laboratory - Organic Chemistry - M110019
Title: Laboratoř specializace - organická chemie
Guaranteed by: Department of Organic Chemistry (110)
Actual: from 2019
Semester: winter
Points: winter s.:7
E-Credits: winter s.:7
Examination process: winter s.:
Hours per week, examination: winter s.:0/10 MC [hours/week]
Capacity: unknown / unlimited (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type:  
Additional information: http://Předmět je vyučován jen v ZS
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Kvíčala Jaroslav prof. Ing. CSc.
Rybáčková Markéta Ing. Ph.D.
Interchangeability : N110017
Annotation -
Last update: Rybáčková Markéta Ing. Ph.D. (31.07.2019)
The aim of the subject is to acquire both theoretical and experimental knowledge of modern laboratory techniques. Among the performed experiments are cross-coupling reactions, photochemical reactions and other reactions that require handling of organometallic and hydride reagents, working under inert atmosphere using inert lines and septum techniques, working in a glovebox, working at low temperatures and with low-boiling liquids. Significant part of the course is devoted to the work on research project in the laboratory of student's tutor.
Aim of the course -
Last update: Rybáčková Markéta Ing. Ph.D. (06.08.2019)

Students will be able to:

work under inert atmosphere using an inert line and septum techniques

work at low temperatures

work in a glovebox

work with low-boiling liquids

work with organometallic and hydride reagents

measure UV spectra and analyse a reaction mixture by HPLC

Literature -
Last update: Rybáčková Markéta Ing. Ph.D. (01.11.2019)

The literature is determined individually for each student by his or her supervisor.

Learning resources -
Last update: Rybáčková Markéta Ing. Ph.D. (31.07.2019)

Printed experiment procedures.

Teaching methods -
Last update: Rybáčková Markéta Ing. Ph.D. (31.07.2019)

Students will attend a laboratory technique course (1st - 4th week of semester, entry 1-8 according to syllabus). Further work will be carried out in specialized laboratories (5th – 14th week of semester). Organization of specialized laboratories will be settled with the student's supervisor.

Syllabus -
Last update: Rybáčková Markéta Ing. Ph.D. (06.08.2019)

1. Determination of unknown concentration of butyllithium solution – working under inert atmosphere using inert lines and septum techniques.

2. Birch reduction of o-xylene – working with low-boiling liquids, working at low temperature, determination of reaction conversion by NMR spectroscopy.

3. Reduction of a carboxylic acid ester – working with hydride reagents under inert atmosphere, crystallization, determination of product purity by NMR spectroscopy.

4. Acylation of cyclohexanone - utilization of enamines in organic synthesis, working with Dean-Stark apparatus, vacuum distillation.

5. Horner-Wadsworth-Emmons reaction – working with sodium hydride under inert atmosphere, crystallization, determination of product purity by NMR spectroscopy.

6. Negishi cross-coupling – working with organozinc reagents under inert atmosphere, column chromatography.

7. Photochemical oxidation of sulfides to sulfoxides – measurement of UV spectra, calculation of extinction coefficient, weighing on an analytical balance, analysis of the reaction mixture by HPLC.

8. Ring-closing metathesis – working in a glovebox, kinetic study using NMR spectroscopy.

9. Research project in a specialized laboratory.

Registration requirements -
Last update: Kundrát Ondřej Ing. Ph.D. (22.02.2018)

No.

Course completion requirements -
Last update: Rybáčková Markéta Ing. Ph.D. (06.08.2019)

Defense of an individual project.

Teaching methods
Activity Credits Hours
Účast v laboratořích (na exkurzi nebo praxi) 5 140
Obhajoba individuálního projektu 0,1 2
Práce na individuálním projektu 1,9 54
7 / 7 196 / 196
Coursework assessment
Form Significance
Regular attendance 20
Report from individual projects 20
Defense of an individual project 60

 
VŠCHT Praha