SubjectsSubjects(version: 949)
Course, academic year 2019/2020
  
Specialized Laboratory - Organic Chemistry - M110019
Title: Laboratoř specializace - organická chemie
Guaranteed by: Department of Organic Chemistry (110)
Faculty: Faculty of Chemical Technology
Actual: from 2019
Semester: winter
Points: winter s.:7
E-Credits: winter s.:7
Examination process: winter s.:
Hours per week, examination: winter s.:0/10, MC [HT]
Capacity: unknown / unlimited (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Level:  
For type:  
Additional information: http://Předmět je vyučován jen v ZS
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Kvíčala Jaroslav prof. Ing. CSc.
Rybáčková Markéta Ing. Ph.D.
Class: Základní laboratoře
Interchangeability : N110017
Examination dates   Schedule   
Annotation -
Last update: Rybáčková Markéta Ing. Ph.D. (11.09.2023)
The aim of the subject is to acquire both theoretical and experimental knowledge of modern laboratory techniques. Among the performed experiments are cross-coupling reactions, photochemical reactions and other reactions that require handling of organometallic and hydride reagents, working under inert atmosphere using inert lines and septum techniques, working in a glovebox, working with a microwave reactor, working at low temperatures and with low-boiling liquids. The products obtained will be isolated by advanced separation techniques (vacuum distillation, crystallization and column chromatography) and their structure and purity will be determined by selected analytical methods (NMR spectroscopy, TLC, UV/VIS spectroscopy).
Aim of the course -
Last update: Rybáčková Markéta Ing. Ph.D. (11.09.2023)

Students will be able to:

work under inert atmosphere using an inert line and septum techniques

work at low temperatures

work in a glovebox

work with a microwave reactor

work with an instrument for flash chromatography

work with low-boiling liquids

work with organometallic and hydride reagents

measure UV spectra and analyse a reaction mixture by HPLC

Literature -
Last update: Rybáčková Markéta Ing. Ph.D. (11.09.2023)

Printed experiment procedures.

Learning resources -
Last update: Rybáčková Markéta Ing. Ph.D. (11.09.2023)

Printed experimental procedures.

Syllabus -
Last update: Rybáčková Markéta Ing. Ph.D. (11.09.2023)

1. Determination of unknown concentration of butyllithium solution – working under inert atmosphere using inert lines and septum techniques.

2. Birch reduction of o-xylene – working with low-boiling liquids, working at low temperature, determination of reaction conversion by NMR spectroscopy.

3. Reduction of a carboxylic acid ester – working with hydride reagents under inert atmosphere, crystallization, determination of product purity by NMR spectroscopy.

4. Acylation of cyclohexanone - utilization of enamines in organic synthesis, working with Dean-Stark apparatus, vacuum distillation.

5. Horner-Wadsworth-Emmons reaction – working with sodium hydride under inert atmosphere, crystallization, determination of product purity by NMR spectroscopy.

6. Negishi cross-coupling – working with organozinc reagents under inert atmosphere, column chromatography.

7. Photochemical oxidation of sulfides to sulfoxides – measurement of UV spectra, calculation of extinction coefficient, weighing on an analytical balance, analysis of the reaction mixture by HPLC.

8. Ring-closing metathesis – working in a glovebox, kinetic study using NMR spectroscopy.

9. Microwave heating in organic synthesis - working with a microwave reactor, identification of an unknown sample.

10. Introduction into separation techniques in organic synthesis - separation of a product mixture via flash chromatography.

Registration requirements -
Last update: Kundrát Ondřej Ing. Ph.D. (22.02.2018)

No.

Course completion requirements -
Last update: Rybáčková Markéta Ing. Ph.D. (06.08.2019)

Defense of an individual project.

Teaching methods
Activity Credits Hours
Účast v laboratořích (na exkurzi nebo praxi) 5 140
5 / 7 140 / 196
Coursework assessment
Form Significance
Regular attendance 20
Report from individual projects 20
Defense of an individual project 60

 
VŠCHT Praha