SubjectsSubjects(version: 855)
Course, academic year 2019/2020
  
Separation Processes - M111005
Title: Separační procesy
Guaranteed by: Department of Organic Technology (111)
Actual: from 2019
Semester: summer
Points: summer s.:5
E-Credits: summer s.:5
Examination process: summer s.:
Hours per week, examination: summer s.:2/2 C+Ex [hours/week]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Level:  
For type: Master's (post-Bachelor)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Čapek Pavel doc. Ing. CSc.
Interchangeability : N111016
Examination dates   Schedule   
This subject contains the following additional online materials
Annotation -
Last update: Čapek Pavel doc. Ing. CSc. (14.02.2018)
Emphasis is put on the theory and application of modern separation processes in the chemical and pharmaceutical industry. Students gain a background suitable for design, control and intensification of separation processes. The course embraces elements of chemical engineering, physical chemistry, mathematics and analytical chemistry. The understanding of preparative liquid chromatography and adsorption processes is supported by including lessons focused on adsorption theory and determination of adsorption isotherms.
Aim of the course -
Last update: Kubová Petra Ing. (23.02.2018)

Students will be able to:

1. Develop mass and energy balances of separation apparatuses.

2. Analyse and optimise separation processes in chemical and pharmaceutical industry.

3. Design a suitable approach for scaling up a process from the laboratory to production scale.

Literature -
Last update: Čapek Pavel doc. Ing. CSc. (14.02.2018)

R: J. D. Seader, E. J. Henley: Separation Process Principles, 2nd edition, John Wiley & Sons, New York (2006), 0470481838.

A: R. B. Bird, W. E. Stewart, E. N. Lightfoot: Transport Phenomena, 2nd edition, John Wiley & Sons, New York (2007), 0470115394.

A: R. C. Reid, J. M. Prausnitz, B. E. Poling: The Properties of Gases & Liquids, 4th edition, McGraw-Hill, Boston (1987), 0470115394.

A: D. M. Ruthven: Principles of Adsorption and Adsorption Processes, John Wiley & Sons, New York (1984), 0471866067.

A: R. Taylor, R. Krishna: Multicomponent Mass Transfer, John Wiley & Sons, New York (1993), 0471574171.

Learning resources -
Last update: Kubová Petra Ing. (04.01.2018)

The lecturer provides students with copies of lectures in the PDF format on request.

Requirements to the exam -
Last update: Kubová Petra Ing. (04.01.2018)

two/three written tests and oral examination

Syllabus -
Last update: Kubová Petra Ing. (04.01.2018)

Syllabus

1. Introduction and the course justification

Specific position of small-scale technologies in chemical industry, features of pharmaceutical processes,

scale-up in engineering of pharmaceutical processes, design and optimization of batch processes, more complex

cases of process development

2. Material and Enthalpy Balances

Rules for formulation of balances, derivation of equations, a typical apparatus - a column with

the counter-current flow of phases, solution of equations

3. Liquid Extraction (Solvent Extraction)

Solvent selection, types of extractors, process design, mass balance, solutions of non-linear equations, a

case study

4. Solid -- Liquid Extraction (Leaching, Percolation, Infusion)

Definition (mechanism, process methods), examples of applications, types of extractors, process design, mass

balance, numerical solution of non-linear equations, process control, an example of calculation

5. Supercritical Extraction

Definition, thermodynamic basis, types of extractors, process design, process control, industrial applications

6. Liquid Chromatography

Introduction and definitions, classification, techniques (methods), equipment, stationary and mobile phases

7. Adsorption

Definitions and basic quantities, Gibbs adsorption isotherm, models of adsorption isotherms, multicomponent

adsorption isotherms, estimation of isotherm parameters

8. Preparative Liquid Chromatography

Models of chromatographic columns, process design, equilibrium data acquisition

9. Adsorption Processes

Microporous adsorbents, basic characteristics of the processes, cyclic batch systems (CBS), desorption

(regeneration) methods for CBS, continuous countercurrent systems (CCS), comparison of chromatographic

processes and CCS

10. Freeze Drying (Lyophilization)

Introduction, benefits of freeze drying, freezing, freeze drying, rates of freeze drying, process equipment

11. Membranes and Mass Transfer

Introduction, fundamentals, principles of membrane processes, mass transfer in membranes, types of membranes

12. Membrane Separation Processes

Types of membrane processes, preparation and membrane module construction, concentration polarisation and

membrane fouling

13. Crystallisation

Basic definitions, phase equilibrium, basic balances, formation of nuclei, kinetics of crystal growth,

hydrodynamic properties of suspensions, control of crystal shape, product properties, methods of

crystallisation, sublimation and desublimation

14. Crystallisers

classification of crystallisers, design of crystallisers

Entry requirements -
Last update: Kubová Petra Ing. (04.01.2018)

chemical engineering, physical chemistry, analytical chemistry, mathematics and basic programming in MATLAB

Registration requirements -
Last update: Čapek Pavel doc. Ing. CSc. (14.02.2018)

Mathematics I

Physical Chemistry I

Unit Operations of Chemical Engineering I

Course completion requirements - Czech
Last update: Patera Jan Ing. Ph.D. (21.02.2018)

Studenti musí úspěšně napsat 3 zápočtové testy a následně uspět u ústní zkoušky.

Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0,4 10
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1 28
Práce na individuálním projektu 0,1 4
Příprava na zkoušku a její absolvování 1,5 42
Účast na seminářích 1 28
5 / 5 140 / 140
Coursework assessment
Form Significance
Regular attendance 10
Report from individual projects 10
Continuous assessment of study performance and course -credit tests 40
Oral examination 40

 
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