SubjectsSubjects(version: 955)
Course, academic year 2019/2020
Biochemistry of Secondary Metabolites - M319002
Title: Biochemie sekundárních metabolitů
Guaranteed by: Department of Biotechnology (319)
Faculty: Faculty of Food and Biochemical Technology
Actual: from 2019
Semester: summer
Points: summer s.:4
E-Credits: summer s.:4
Examination process: summer s.:
Hours per week, examination: summer s.:2/1, C+Ex [HT]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
State of the course: taught
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Masák Jan prof. Ing. CSc.
Interchangeability : N319011
Examination dates   Schedule   
This subject contains the following additional online materials
Annotation -
A number of secondary metabolites are among important biotech products used in medicine, food and chemical industry and in many other areas of human activity. Although metabolic pathways for the synthesis of these compounds are based on metabolites of the general (primary) metabolism, they are specific to particular groups of organisms and have different regulatory mechanisms. The lectures explain the general relationships between primary and secondary metabolism and evolution of metabolic pathways of secondary metabolism. After a survey of the individual groups of secondary metabolites, closer attention is paid to microbial and plant compounds such as antibiotics, cancerostatics, alkaloids, terpenic oils etc.. In detail are discussed its biosynthetic pathways, physico-chemical properties, biological activity, the mechanisms of interaction with other organisms and resistance to their effects. Part of the seminar is an individual work devoted to a selected group of secondary metabolites.
Last update: Hladíková Jana (12.12.2017)
Aim of the course -

Students will be able to:

characterize important groups or individual compounds produced by secondary metabolism;

describe the important metabolic pathways for the synthesis of secondary metabolites and their regulation;

propose application of the most important secondary metabolites;

recognize the risks associated with the mechanism and evolution of resistance to secondary metabolites such as used in medicine, food, etc.

Last update: Hladíková Jana (12.12.2017)
Literature -

R:Rehm,H.-J.,Reed G.: Biotechnology: Products of Secondary Metabolism, Vol 7, 2nd Ed, Wiley, Weinheim, 2008, 9783527620890

A:Cole,R.J.: Handbook of Secondary Fungal Metabolites, Elsevier, New York,2003, 978012179606

R:Carocho, M., Heleno, S.M., Barros, L.: Natural Secondary Metabolites, Springer, Cham 2023, 2006, 9783031185861

Last update: Masák Jan (12.09.2023)
Learning resources -

Last update: Masák Jan (03.02.2018)
Requirements to the exam -

Preparation and defense of the seminar paper.

Last update: Masák Jan (03.02.2018)
Syllabus -

1. Introduction - definitions of "secondary metabolism", "secondary metabolite"

2. Origin, evolution and genetic determination of secondary metabolism

3. Distribution and function of secondary metabolism in living organisms

4. List of important metabolic pathways of secondary metabolism and their regulation

5. Overview of the biological activities of secondary metabolites

6. Secondary metabolism in microorganisms

7. Antimicrobial compounds

8. Secondary metabolites with cancerostatic activity

9. Microbial toxins

10. Microbial alkaloids and growth modulators

11. Secondary metabolites produced by plants I

12. Secondary metabolites produced by plants II

13. Resistance mechanisms against the toxic effects of secondary metabolites

14. Current trends in research and application of secondary metabolites

Last update: Hladíková Jana (12.12.2017)
Registration requirements -

Biochemistry, Microbiology, Organic chemistry

Last update: Hladíková Jana (12.12.2017)
Course completion requirements -

Course credit based on the presentation of the seminar paper.

Oral exam.

Last update: Masák Jan (03.02.2018)
Teaching methods
Activity Credits Hours
Účast na přednáškách 1 28
Práce na individuálním projektu 1 28
Příprava na zkoušku a její absolvování 2 56
4 / 4 112 / 112
Coursework assessment
Form Significance
Defense of an individual project 20
Oral examination 80