Bioengineering I - M319004
Title: Bioinženýrství I
Guaranteed by: Department of Biotechnology (319)
Faculty: Faculty of Food and Biochemical Technology
Actual: from 2019 to 2022
Semester: winter
Points: winter s.:4
E-Credits: winter s.:4
Examination process: winter s.:
Hours per week, examination: winter s.:2/1, C+Ex [HT]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
For type: Master's (post-Bachelor)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: Halecký Martin doc. Ing. Ph.D.
Interchangeability : AM319004, N319008
Is interchangeable with: AM319004
Examination dates   
This subject contains the following additional online materials
Annotation -
Last update: Halecký Martin doc. Ing. Ph.D. (16.09.2023)
The course focuses on understanding and quantitative description of biological processes in the context of their implementation under defined conditions enabling to achieve reproducibility of results. The syllabus is based on the principles of kinetics, balancing as well as measurement and regulation of biological processes, including the design of the equipment.
Aim of the course -
Last update: Halecký Martin doc. Ing. Ph.D. (16.09.2023)

Students will be able to:

Understand the biological, chemical and engineering processes in the biotechnology industry

Describe and evaluate basic biocatalytic processes.

Quantitatively evaluate experimental data of processes catalyzed by biological elements and to carry out heat and mass balances of biotechnological processes.

Design mixing and aeration equipment of bioreactors.

Literature -
Last update: Halecký Martin doc. Ing. Ph.D. (16.09.2023)

R - Meyer H.-P., & Schmidhalter D. (2014). Industrial Scale Suspension Culture of Living Cells. Wiley, ISBN: 978-3-527-68335-2

R - Kresta, S. M., Etchells, A. W., Dickey, D. S., & Atiemo-Obeng, V. A. (2016). Advances in industrial mixing: a companion to the Handbook of industrial mixing. Wiley, ISBN: 9781118944301

R - Katoh S., Horiuchi J., & Yoshida F. (2015). Biochemical Engineering: A Textbook for Engineers, Chemists and Biologists. Wiley, ISBN: 9783527338047

Learning resources -
Last update: Halecký Martin doc. Ing. Ph.D. (16.09.2023)

Syllabus -
Last update: Halecký Martin doc. Ing. Ph.D. (16.09.2023)

1. The issue of biotechnology and bioengineering.

2. The structure of bioprocess, equipment overview and unit operations.

3. Methods of optimization and modeling of biological processes.

4. Engineering kinetics of chemical and enzymatic reactions, kinetics of microbial growth.

5. Cultivation of microorganisms - batch and fed-batch cell cultures.

6. Cultivation of microorganisms - semicontinuous and continuous cell cultures.

7. Characteristics of phase folw - residence time distribution, flow models.

8. Mass transfer - oxygen transfer, aeration, measurement and quantification of KLa.

9. Specific aspects of plant/tissue cell and phototrophic cell cultivation.

10. Engineering aspects of enzyme and cell immobilization, biocatalysis.

11. Mixing in bioreactors - theory, power consumption, homogenization, shear forces.

12. Heat transfer, energy balance of bioreactors, sterilization, cooling and heating.

13. Scale-up of bioprocesses.

14. Construction materials, corrosion, design and construction of biotechnological processes.

Registration requirements -
Last update: Halecký Martin doc. Ing. Ph.D. (16.09.2023)
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Course completion requirements -
Last update: Brányik Tomáš prof. Ing. Ph.D. (23.01.2018)

Credit test (rated at least 50%).

Exam test (rated at least 50%).

Oral exam.

Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0.2 6
Účast na přednáškách 1 28
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 0.5 14
Příprava na zkoušku a její absolvování 1.8 50
Účast na seminářích 0.5 14
4 / 4 112 / 112