SubjectsSubjects(version: 941)
Course, academic year 2019/2020
Pathobiochemistry I - M320008
Title: Pathobiochemie I
Guaranteed by: Department of Biochemistry and Microbiology (320)
Faculty: Faculty of Food and Biochemical Technology
Actual: from 2019 to 2020
Semester: winter
Points: winter s.:5
E-Credits: winter s.:5
Examination process: winter s.:
Hours per week, examination: winter s.:3/0, Ex [HT]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
For type: Master's (post-Bachelor)
Guarantor: Šebesta Ivan MUDr. CSc.
Jirsa Milan prof. MUDr. Mgr. CSc.
Interchangeability : N320032
Examination dates   Schedule   
Annotation -
Last update: Hladíková Jana (13.12.2017)
The goal of the subject is to acquire basic pathobiochemistry processes in the human body. The course emphasizes a comprehensive explanation of the mechanisms of disease development at the level of tissues, cells and molecular biology,too. Students are also acquainted with effective indication and interpretation of basic biochemical tests. The latest research findings and treatment of diseases with high frequency (lifestyle diseases) are also presented.
Aim of the course -
Last update: Hladíková Jana (13.12.2017)

Students will be able to:

  • get knowledge of pathobiochemistry mechanisms of disease development
  • correctly interpret basic clinical biochemistry tests in their future practice
Literature -
Last update: Hochel Igor doc. Ing. CSc. (31.01.2018)

R:Masopust J., Patobiochemie buňky. ČSKB, 2.LF UK, 2003, 80-239-1011-0

R:Masopust J., Průša R., Patobiochemie metabolických drah. 2.LFUK, 1999, 80-238-4589-6

R:Kalousová M. a kol. Patobiochemie ve schématech.Grada Publishing, 2006, 80-247-1522-8

R:Racek J. a kol.. Klinická biochemie.2.vydání, Praha, Galén, Karolinum, 2006, 80-7262-324-9

R:Štern P.a kol: Obecná a klinická biochemie. Karolinum, Praha 2011, 978-80-246-1979-8

R:Karlson P., Gerok W., Gross W.: Pathobiochemie. Academia, Praha 1987 (nemá ISBN)

A:Zima T. ed. Laboratorní diagnostika. třetí, doplněné a přepracované vydání, Praha, Galén, 2013, 978-80-7262-372-3(Galén), 978-80-246-1423-6 (Karolinum)

Learning resources -
Last update: Hladíková Jana (13.12.2017)

Syllabus -
Last update: Hochel Igor doc. Ing. CSc. (31.01.2018)

1.Patobiochemistry of the cell, organs and tissues

2.Disorders of carbohydrate metabolism - diabetes mellitus

3.Disorders of lipoproteins metabolism, atherosclerosis

4.Regulation of water and ions in human body and their disturbances

5.Pathobiochemistry of kidney

6.Pathobiochemistry of endocrine system

7.Pathobiochemistry of cardiovascular disorders

8.Metabolic disorders

9.Pathobiochemistry of liver,porphyrias, dif.dg.of jaundice

10.Pathobiochemistry of gastrointestinal disorders

11.Pathobiochemistry of blood and erythropoiesis

12.Genetic disorders of metabolism

13.Pathobiochemistry of cancers, tumor markers

14.Cancer cytogenetics

Registration requirements -
Last update: Hochel Igor doc. Ing. CSc. (31.01.2018)


Teaching methods
Activity Credits Hours
Konzultace s vyučujícími 0.5 14
Účast na přednáškách 1.5 42
Příprava na přednášky, semináře, laboratoře, exkurzi nebo praxi 1.5 42
Příprava na zkoušku a její absolvování 1.5 42
5 / 5 140 / 140
Coursework assessment
Form Significance
Regular attendance 10
Oral examination 90