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The subject widens the basic knowledge of biochemistry of microorganisms targeted on the organization of cell metabolism and their regulatory mechanisms. Cell cycle regulation of prokaryotes and eukaryotes is part of this. Biochemical principles of extremophilic microorganisms are included.Next topics are determinants of pathogens virulence, synthesis of antimicrobials peptides and antibiotics (secondary metabolites). The quorum-sensing regulation and the formation of bacterial biofilm are explained.
Last update: Hladíková Jana (13.12.2017)
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Only the student, who previously presented and defended the individual project on selected topic, can write final exam test and pass the oral exam. The successful completion of the course consists of the written test (min. 50 points out of 100) and oral examination in A-E grade. Last update: Stiborová Hana (06.02.2018)
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Brock Biology of Microorganisms (15th Edition), Michael T. Madigan, Kelly S. Bender , Daniel H. Buckley, W. Matthew Sattley, David A. Stahl, (2018), ISBN-13: 978-0321649638 Microbial Biochemistry (4th Edition), Georges N. Cohen, (ed. 2016), ISBN-10: 940177577X Bacterial Physiology and Metabolism, Byung Hong Kim, Geoffrey Michael Gadd, Cambridge University Press; 1 edition (2008), ISBN-10: 0521712300 Last update: Stiborová Hana (09.02.2018)
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1. Introduction. Cell metabolism organization. 2. DNA replication and repair, transcription and regulation, translation 3. Life and cell cyclus of prokaryotic and eukaryotic microorganisms, cytoskeleton. 4. Bioenergetics of microorganisms. 5. Biochemistry and adaptation mechanisms of extremophiles. 6. Synthesis of essentials amino acids. 7. Synthesis of secondary metabolites, antibiotic`s mechanism of action. 8. Inhibitory factors produced by microorganisms - antibiotics, colicines, killer factors. 9. Factors determining microorganisms patogenity. 10. Secretion system of prokaryotic and eukaryotic microorganisms. 11. Transport mechanisms in microorganisms. 12. Life cycles of microorganisms: biochemistry, regulation, and communication „Quorum sensing“. 13. Oxidative stress of microorganisms. 14. Microbial enzymes in biotechnology.
Last update: Kubová Petra (14.12.2018)
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none Last update: Hladíková Jana (13.12.2017)
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Student will gain the knowledge in these fields:
Last update: Stiborová Hana (06.02.2018)
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Biochemistry, Mikrobiology Last update: Hladíková Jana (13.12.2017)
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Teaching methods | ||||
Activity | Credits | Hours | ||
Obhajoba individuálního projektu | 0.3 | 8 | ||
Účast na přednáškách | 1 | 28 | ||
Příprava na zkoušku a její absolvování | 1.7 | 48 | ||
3 / 3 | 84 / 84 |